Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system that
involves demyelination and axonal degeneration. Although substantial progress has been …

Atherosclerosis is one type of cardiovascular disease (CVD) in which activation of the
NLRP3 inflammasome and toll-like receptor (TLR) pathways is implicated. One of the most …

Cholesterol is a multifaceted metabolite that is known to modulate processes in cancer,
atherosclerosis, and autoimmunity. A common denominator between these diseases …

Life expectancy has been on the rise for the past few decades, but healthy life expectancy
has not kept pace, leading to a global burden of age-associated disorders. Advancing age is …

Central nervous system B cells have several potential roles in multiple sclerosis (MS):
secretors of proinflammatory cytokines and chemokines, presenters of autoantigens to T …

Background Secondary progressive multiple sclerosis, for which no satisfactory treatment
presently exists, accounts for most of the disability in patients with multiple sclerosis …

A hallmark of cancer cells includes a metabolic reprograming that provides energy, the
essential building blocks, and signaling required to maintain survival, rapid growth …

Atherosclerosis is the build-up of fatty deposits in the arteries. Atherosclerosis is the main
underlying cause of cardiovascular diseases and the leading cause of global morbidity and …

Immune responses participate in every phase of atherosclerosis. There is increasing
evidence that both adaptive and innate immunity tightly regulate atherogenesis. Although …

Statins, among the most commonly prescribed drugs worldwide, are cholesterol-lowering
agents used to manage and prevent cardiovascular and coronary heart diseases. Recently …