This paper is the third in a series of reviews published in this issue resulting from the
University of California Davis Cardiovascular Symposium 2014: Systems approach to …

The SLC8 gene family encoding Na+/Ca2+ exchangers (NCX) belongs to the CaCA
(Ca2+/Cation Antiporter) superfamily. Three mammalian genes (SLC8A1, SLC8A2, and …

Abstract Na+/Ca2+ exchangers (NCX) transport Ca2+ in or out of cells in exchange for Na+.
They are ubiquitously expressed and play an essential role in maintaining cytosolic Ca2+ …

NCX proteins explore the electrochemical gradient of Na+ to mediate Ca 2+-fluxes in
exchange with Na+ either in the Ca 2+-efflux (forward) or Ca 2+-influx (reverse) mode …

Ca 2+ homeostasis is essential for cell function and survival. As such, the cytosolic Ca 2+
concentration is tightly controlled by a wide number of specialized Ca 2+ handling proteins …

Abstract Structure-dynamic analysis of archaeal NCX (NCX_Mj) provided new insights into
the underlying mechanisms of ion selectivity, ion-coupled alternating access, ion occlusion …

The plasma-membrane homeostasis Na+/Ca2+ exchangers (NCXs) mediate Ca2+
extrusion/entry to dynamically shape Ca2+ signaling/in biological systems ranging from …

Na+/Ca2+ exchanger (NCX) proteins extrude Ca2+ from the cell to maintain cellular
homeostasis. Since NCX proteins contribute to numerous physiological and …

The cardiac Na+/Ca 2+ exchanger (NCX) regulates cellular [Ca 2+] i and plays a central role
in health and disease, but its molecular regulation is poorly understood. Here we report on …

Calcium (Ca2+) plays many important regulatory roles in cardiac muscle cells. In the initial
phase of the action potential, influx of Ca2+ through sarcolemmal voltage‐gated L‐type …