Primary ovarian insufficiency is a subclass of ovarian dysfunction in which the cause is
within the ovary. In most cases, an unknown mechanism leads to premature exhaustion of …

The classical view of ovarian follicle development is that it is regulated by the hypothalamic-
pituitary-ovarian axis, in which gonadotropin-releasing hormone (GnRH) controls the …

Massively parallel sequencing technology and the associated rapidly decreasing
sequencing costs have enabled systemic analyses of somatic mutations in large cohorts of …

Granulosa cell tumors of the ovary represent∼ 5% of malignant ovarian cancers. It has
recently been reported that 95–97% of adult granulosa cell tumors carry a unique somatic …

Granulosa cell tumors of the ovary (GCT) comprise a distinct subset of ovarian cancers that
account for approximately 5% of all ovarian malignancies. They are thought to arise from …

The pituitary gonadotropin hormones, FSH and LH, are key regulators of reproductive
physiology. Though the two hormones are produced by the same cell type, often in response …

Sex cord-stromal tumours (SCSTs) consist of a heterogeneous group of neoplasms with
diverse clinicopathological features and biological behaviour. They often present as a …

The forkhead box transcription factor FOXO1 is highly expressed in granulosa cells of
growing follicles but is down-regulated by FSH in culture or by LH-induced luteinization in …

Foxl2 is a member of the large family of Forkhead Box (Fox) domain transcription factors. It
emerged during the last 15 years as a key player in ovarian differentiation and oogenesis in …

Here we present the Transcription Factor Encyclopedia (TFe), a new web-based
compendium of mini review articles on transcription factors (TFs) that is founded on the …