Astrocytes are the most abundant glial cell in the central nervous system and are involved in
multiple processes including metabolic homeostasis, blood brain barrier regulation and …

Cholesterol is an essential molecule of life, and its synthesis can be inhibited by both
genetic and nongenetic mechanisms. Hundreds of chemicals that we are exposed to in our …

Seminal studies using post-mortem brains of patients with Alzheimer's disease evidenced
aberrant insulin-like growth factor 1 receptor (IGF1R) signalling. Addressing causality, work …

Background DHCR24, involved in the de novo synthesis of cholesterol and protection of
neuronal cells against different stress conditions, has been shown to be selectively …

Objective (s): Glutamate is the most widespread neurotransmitter in the central nervous
system and has several functions as a neuromodulator in the brain although in pathological …

Microglial phenotypic polarization, divided into pro-inflammatory “M1” phenotype and anti-
inflammatory “M2” phenotype, played a crucial role in the pathogenesis of Alzheimer's …

Visceral adiposity has been associated with altered microstructural properties of white
matter in adolescents. Previous evidence suggests that circulating phospholipid PC (16: 0/2 …

Neonatal encephalopathy (NE) results from impaired cerebral blood flow and oxygen
delivery to the brain. The pathophysiology of NE is complex and our understanding of its …

Astrocytes play pivotal roles in regulating glutamate homeostasis at tripartite synapses.
Inhibition of soluble epoxide hydrolase (sEHi) provides neuroprotection by blocking the …

Acute ischemic stroke (AIS) is the most prevalent type of stroke, and due to its high
incidence, disability rate, and mortality rate, it imposes a significant burden on the health …