Advances in germline predisposition to acute leukaemias and myeloid neoplasms
JM Klco, CG Mullighan - Nature Reviews Cancer, 2021 - nature.com
Although much work has focused on the elucidation of somatic alterations that drive the
development of acute leukaemias and other haematopoietic diseases, it has become …
development of acute leukaemias and other haematopoietic diseases, it has become …
Hyperdiploidy: the longest known, most prevalent, and most enigmatic form of acute lymphoblastic leukemia in children
OA Haas, A Borkhardt - Leukemia, 2022 - nature.com
Hyperdiploidy is the largest genetic entity B-cell precursor acute lymphoblastic leukemia in
children. The diagnostic hallmark of its two variants that will be discussed in detail herein is …
children. The diagnostic hallmark of its two variants that will be discussed in detail herein is …
Nested epistasis enhancer networks for robust genome regulation
Mammalian genomes have multiple enhancers spanning an ultralong distance (>
megabases) to modulate important genes, but it is unclear how these enhancers coordinate …
megabases) to modulate important genes, but it is unclear how these enhancers coordinate …
An intact gut microbiome protects genetically predisposed mice against leukemia
C Vicente-Dueñas, S Janssen… - Blood, The Journal …, 2020 - ashpublications.org
The majority of childhood leukemias are precursor B-cell acute lymphoblastic leukemias (pB-
ALLs) caused by a combination of prenatal genetic predispositions and oncogenic events …
ALLs) caused by a combination of prenatal genetic predispositions and oncogenic events …
Heterozygous BRCA1 and BRCA2 and Mismatch Repair Gene Pathogenic Variants in Children and Adolescents With Cancer
Background Genetic predisposition is has been identified as a cause of cancer, yet little is
known about the role of adult cancer predisposition syndromes in childhood cancer. We …
known about the role of adult cancer predisposition syndromes in childhood cancer. We …
Single-cell RNA-seq dissects the intratumoral heterogeneity of triple-negative breast cancer based on gene regulatory networks
S Zhou, Y Huang, H Liu, X Zhou, M Yuan, F Hou… - … Therapy-Nucleic Acids, 2021 - cell.com
Triple-negative breast cancer (TNBC) is a subtype of breast cancer with high intratumoral
heterogeneity. Recent studies revealed that TNBC patients might comprise cells with distinct …
heterogeneity. Recent studies revealed that TNBC patients might comprise cells with distinct …
Genomic landscape of Down syndrome–associated acute lymphoblastic leukemia
Trisomy 21, the genetic cause of Down syndrome (DS), is the most common congenital
chromosomal anomaly. It is associated with a 20-fold increased risk of acute lymphoblastic …
chromosomal anomaly. It is associated with a 20-fold increased risk of acute lymphoblastic …
Genetic determinants of blood-cell traits influence susceptibility to childhood acute lymphoblastic leukemia
Acute lymphoblastic leukemia (ALL) is the most common childhood cancer. Despite overlap
between genetic risk loci for ALL and hematologic traits, the etiological relevance of …
between genetic risk loci for ALL and hematologic traits, the etiological relevance of …
RNA binding protein IGF2BP1 synergizes with ETV6-RUNX1 to drive oncogenic signaling in B-cell Acute Lymphoblastic Leukemia
G Sharma, TM Tran, I Bansal, MS Beg… - Journal of Experimental …, 2023 - Springer
Background Acute lymphoblastic leukemia (ALL) is the most common pediatric
hematological malignancy, with ETV6:: RUNX1 being the most prevalent translocation …
hematological malignancy, with ETV6:: RUNX1 being the most prevalent translocation …
Toward prevention of childhood ALL by early-life immune training
J Hauer, U Fischer, A Borkhardt - Blood, The Journal of the …, 2021 - ashpublications.org
B-cell precursor acute lymphoblastic leukemia (BCP-ALL) is the most common form of
childhood cancer. Chemotherapy is associated with life-long health sequelae and fails in∼ …
childhood cancer. Chemotherapy is associated with life-long health sequelae and fails in∼ …