High-throughput methods in the discovery and study of biomaterials and materiobiology
The complex interaction of cells with biomaterials (ie, materiobiology) plays an increasingly
pivotal role in the development of novel implants, biomedical devices, and tissue …
pivotal role in the development of novel implants, biomedical devices, and tissue …
The role of changes in extracellular matrix of cartilage in the presence of inflammation on the pathology of osteoarthritis
M Maldonado, J Nam - BioMed research international, 2013 - Wiley Online Library
Osteoarthritis (OA) is a degenerative disease that affects various tissues surrounding joints
such as articular cartilage, subchondral bone, synovial membrane, and ligaments. No …
such as articular cartilage, subchondral bone, synovial membrane, and ligaments. No …
Collagen scaffolds in cartilage tissue engineering and relevant approaches for future development
Background: Cartilage tissue engineering (CTE) aims to obtain a structure mimicking native
cartilage tissue through the combination of relevant cells, three-dimensional scaffolds, and …
cartilage tissue through the combination of relevant cells, three-dimensional scaffolds, and …
3D culture of chondrocytes in gelatin hydrogels with different stiffness
Gelatin hydrogels can mimic the microenvironments of natural tissues and encapsulate cells
homogeneously, which makes them attractive for cartilage tissue engineering. Both the …
homogeneously, which makes them attractive for cartilage tissue engineering. Both the …
Extracellular matrix stiffness dictates Wnt expression through integrin pathway
J Du, Y Zu, J Li, S Du, Y Xu, L Zhang, L Jiang… - Scientific reports, 2016 - nature.com
It is well established that extracellular matrix (ECM) stiffness plays a significant role in
regulating the phenotypes and behaviors of many cell types. However, the mechanism …
regulating the phenotypes and behaviors of many cell types. However, the mechanism …
Effect of gelatin source and photoinitiator type on chondrocyte redifferentiation in gelatin methacryloyl-based tissue-engineered cartilage constructs
Gelatin methacryloyl (GelMA) hydrogels are a mechanically and biochemically tuneable
biomaterial, facilitating chondrocyte culture for tissue engineering applications. However, a …
biomaterial, facilitating chondrocyte culture for tissue engineering applications. However, a …
[HTML][HTML] Steering cell behavior through mechanobiology in 3D: a regenerative medicine perspective
J Zonderland, L Moroni - Biomaterials, 2021 - Elsevier
Mechanobiology, translating mechanical signals into biological ones, greatly affects cellular
behavior. Steering cellular behavior for cell-based regenerative medicine approaches …
behavior. Steering cellular behavior for cell-based regenerative medicine approaches …
Controlled positioning of cells in biomaterials—approaches towards 3D tissue printing
Current tissue engineering techniques have various drawbacks: they often incorporate
uncontrolled and imprecise scaffold geometries, whereas the current conventional cell …
uncontrolled and imprecise scaffold geometries, whereas the current conventional cell …
Stiffness matters: fine-tuned hydrogel elasticity alters chondrogenic redifferentiation
B Bachmann, S Spitz, B Schädl, AH Teuschl… - … in Bioengineering and …, 2020 - frontiersin.org
Biomechanical cues such as shear stress, stretching, compression, and matrix elasticity are
vital in the establishment of next generation physiological in vitro tissue models. Matrix …
vital in the establishment of next generation physiological in vitro tissue models. Matrix …
ECM stiffness primes the TGFβ pathway to promote chondrocyte differentiation
JL Allen, ME Cooke, T Alliston - Molecular biology of the cell, 2012 - Am Soc Cell Biol
Cells encounter physical cues such as extracellular matrix (ECM) stiffness in a
microenvironment replete with biochemical cues. However, the mechanisms by which cells …
microenvironment replete with biochemical cues. However, the mechanisms by which cells …