For many decades, the design of new nucleoside analogs as potential therapeutic agents
focused on both sugar and nucleobase modifications. These nucleoside analogs rely on …

Varicella-zoster virus (VZV), a common and ubiquitous human-restricted pathogen, causes a
primary infection (varicella or chickenpox) followed by establishment of latency in sensory …

A substantial portion of metabolism involves transformation of phosphate esters, including
pathways leading to nucleotides and oligonucleotides, carbohydrates, isoprenoids and …

The use of the phosphonate motif featuring a carbon-phosphorous bond as bioisosteric
replacement of the labile P–O bond is widely recognized as an attractive structural concept …

Considerable attention has been focused on the development of phosphonate-containing
drugs for application in many therapeutic areas. However, phosphonate diacids are …

The fluorine atom plays an important role in medicinal chemistry because fluorine
substitution has a strong impact on the physical, chemical, and biological properties of …

In the present work, 103 novel acyclic nucleosides were designed, synthesized, and
evaluated for their anticancer activities in vitro and in vivo. The structure–activity relationship …

Thymidylate kinase (TMPK) is a key enzyme for pyrimidine synthesis that catalyzes the
phosphorylation of thymidine 5'-monophosphate (dTMP) in the presence of ATP and Mg2+ …

A new and facile synthetic pathway to metabolically stable 5′-methylene-bis
(pivaloyloxymethyl)(POM) phosphonate furanonucleoside prodrugs is reported. The key …

In this study, a novel series of pyrimidine compounds featuring azo linkages was
synthesized via a sequence of stepwise and one-pot three-component reactions. The …