Structural basis of the recognition of adeno-associated virus by the neurological system-related receptor carbonic anhydrase IV
R Zhang, Y Liu, F Yu, G Xu, L Li, B Li, Z Lou - Plos Pathogens, 2024 - journals.plos.org
Carbonic anhydrase IV (Car4) is a newly identified receptor that allows adeno-associated
virus (AAV) 9P31 to cross the blood-brain barrier and achieve efficient infection in the central …
virus (AAV) 9P31 to cross the blood-brain barrier and achieve efficient infection in the central …
Vector affinity and receptor distribution define tissue-specific targeting in an engineered AAV capsid
RA Martino, Q Wang, H Xu, G Hu, P Bell… - Journal of …, 2023 - Am Soc Microbiol
Unbiased in vivo selections of diverse capsid libraries can yield engineered capsids that
overcome gene therapy delivery challenges like traversing the blood-brain barrier (BBB), but …
overcome gene therapy delivery challenges like traversing the blood-brain barrier (BBB), but …
Fast, accurate ranking of engineered proteins by target-binding propensity using structure modeling
Deep-learning-based methods for protein structure prediction have achieved
unprecedented accuracy, yet their utility in the engineering of protein-based binders remains …
unprecedented accuracy, yet their utility in the engineering of protein-based binders remains …
Fast, accurate ranking of engineered proteins by receptor binding propensity using structure modeling
Deep learning-based methods for protein structure prediction have achieved unprecedented
accuracy. However, the power of these tools to guide the engineering of protein-based …
accuracy. However, the power of these tools to guide the engineering of protein-based …