Retina in a dish: Cell cultures, retinal explants and animal models for common diseases of the retina

S Schnichels, F Paquet-Durand, M Löscher… - Progress in retinal and …, 2021 - Elsevier
For many retinal diseases, including age-related macular degeneration (AMD), glaucoma,
and diabetic retinopathy (DR), the exact pathogenesis is still unclear. Moreover, the currently …

Polysaccharide-based hydrogels for medical devices, implants and tissue engineering: A review

D Sanjanwala, V Londhe, R Trivedi, S Bonde… - International Journal of …, 2024 - Elsevier
Hydrogels are highly biocompatible biomaterials composed of crosslinked three-
dimensional networks of hydrophilic polymers. Owing to their natural origin, polysaccharide …

Polymeric hydrogels as a vitreous replacement strategy in the eye

Q Lin, JYC Lim, K Xue, X Su, XJ Loh - Biomaterials, 2021 - Elsevier
Vitreous endo-tamponades are commonly used in the treatment of retinal detachments and
tears. They function by providing a tamponading force to support the retina after retina …

Stable oxime-crosslinked hyaluronan-based hydrogel as a biomimetic vitreous substitute

AEG Baker, H Cui, BG Ballios, S Ing, P Yan, J Wolfer… - Biomaterials, 2021 - Elsevier
Vitreous substitutes are clinically used to maintain retinal apposition and preserve retinal
function; yet the most used substitutes are gases and oils which have disadvantages …

[HTML][HTML] Functionalized hydrogels in ophthalmic applications: Ocular inflammation, corneal injuries, vitreous substitutes and intravitreal injection

Q Gong, Y Zhao, T Qian, H Wang, Z Li - Materials & Design, 2022 - Elsevier
With the prevalence of eye diseases, such as inflamed eyes, corneal injury, cataract,
glaucoma, and retinal degenerative diseases, different clinical strategies have been …

A highly transparent tri-polymer complex in situ hydrogel of HA, collagen and four-arm-PEG as potential vitreous substitute

I Yadav, SD Purohit, H Singh, N Das, P Roy… - Biomedical …, 2021 - iopscience.iop.org
There is a requirement of removal and replacement of vitreous for various ophthalmic
diseases, eg retinopathy and retinal detachment. Clinical tamponades, eg silicone oil and …

Historical, current and future approaches to surgery for rhegmatogenous retinal detachment

H Kunikata, T Abe, T Nakazawa - The Tohoku journal of …, 2019 - jstage.jst.go.jp
Rhegmatogenous retinal detachment (RRD) is a serious condition that can cause blindness
without surgical treatment. RRD occurs when a retinal tear or hole allows fluid to accumulate …

Vitreous substitutes: An overview of the properties, importance, and development

I Yadav, SD Purohit, H Singh… - … Research Part B …, 2021 - Wiley Online Library
Vitreous or vitreous humor is a complex transparent gel that fills the space between the lens
and retina of an eye and acts as a transparent medium that allows light to pass through it to …

Forward light scattering of first to third generation vitreous body replacement hydrogels after surgical application compared to conventional silicone oils and vitreous …

M Hammer, J Herth, M Muuss, S Schickhardt… - Gels, 2023 - mdpi.com
To treat certain vitreoretinal diseases, the vitreous body, a hydrogel composed of mostly
collagen and hyaluronic acid, must be removed. After vitrectomy surgery, the vitreous cavity …

Current situation and challenges in vitreous substitutes

C Mondelo‐García, E Bandín‐Vilar… - Macromolecular …, 2021 - Wiley Online Library
Vitreo‐retinal disorders constitute a significant portion of treatable ocular diseases. These
pathologies often require vitreo‐retinal surgery and, as a consequence, the use of vitreous …