Circadian rhythm as a therapeutic target

W Ruan, X Yuan, HK Eltzschig - Nature Reviews Drug Discovery, 2021 - nature.com
The circadian clock evolved in diverse organisms to integrate external environmental
changes and internal physiology. The clock endows the host with temporal precision and …

Molecular mechanisms and physiological importance of circadian rhythms

A Patke, MW Young, S Axelrod - Nature reviews Molecular cell biology, 2020 - nature.com
To accommodate daily recurring environmental changes, animals show cyclic variations in
behaviour and physiology, which include prominent behavioural states such as sleep–wake …

Transcriptional architecture of the mammalian circadian clock

JS Takahashi - Nature Reviews Genetics, 2017 - nature.com
Circadian clocks are endogenous oscillators that control 24-hour physiological and
behavioural processes in organisms. These cell-autonomous clocks are composed of a …

[HTML][HTML] The microbiota coordinates diurnal rhythms in innate immunity with the circadian clock

JF Brooks, CL Behrendt, KA Ruhn, S Lee, P Raj… - Cell, 2021 - cell.com
Environmental light cycles entrain circadian feeding behaviors in animals that produce
rhythms in exposure to foodborne bacteria. Here, we show that the intestinal microbiota …

Circadian rhythms and the molecular clock in cardiovascular biology and disease

S Crnko, BC Du Pré, JPG Sluijter… - Nature Reviews …, 2019 - nature.com
The Earth turns on its axis every 24 h; almost all life on the planet has a mechanism—
circadian rhythmicity—to anticipate the daily changes caused by this rotation. The molecular …

Circadian clock genes and the transcriptional architecture of the clock mechanism

KH Cox, JS Takahashi - Journal of molecular endocrinology, 2019 - jme.bioscientifica.com
The mammalian circadian clock has evolved as an adaptation to the 24-h light/darkness
cycle on earth. Maintaining cellular activities in synchrony with the activities of the organism …

The emerging link between cancer, metabolism, and circadian rhythms

S Masri, P Sassone-Corsi - Nature medicine, 2018 - nature.com
The circadian clock is a complex cellular mechanism that, through the control of diverse
metabolic and gene expression pathways, governs a large array of cyclic physiological …

Fasting, circadian rhythms, and time-restricted feeding in healthy lifespan

VD Longo, S Panda - Cell metabolism, 2016 - cell.com
Most animals alternate periods of feeding with periods of fasting often coinciding with sleep.
Upon> 24 hr of fasting, humans, rodents, and other mammals enter alternative metabolic …

Chrono‐nutrition: from molecular and neuronal mechanisms to human epidemiology and timed feeding patterns

A Flanagan, DA Bechtold, GK Pot… - Journal of …, 2021 - Wiley Online Library
The circadian timing system governs daily biological rhythms, synchronising physiology and
behaviour to the temporal world. External time cues, including the light‐dark cycle and …

Interconnections between circadian clocks and metabolism

D Guan, MA Lazar - The Journal of clinical investigation, 2021 - Am Soc Clin Investig
Circadian rhythms evolved through adaptation to daily light/dark changes in the
environment; they are believed to be regulated by the core circadian clock interlocking …