Type 2 diabetes mellitus (T2DM) is closely associated with obesity, while interactions
between the two diseases remain to be fully elucidated. To this point, we offer this …

Qualitative and quantitatively appropriate insulin secretion is essential for optimal control of
blood glucose. Beta-cells of the pancreas produce and secrete insulin in response to …

HumanIslets. com supports diabetes research by offering easy access to islet phenotyping
data, analysis tools, and data download. It includes molecular omics, islet and cellular …

Mediator, a co-regulator complex required for RNA Polymerase II activity, interacts with
tissue-specific transcription factors to regulate development and maintain homeostasis. We …

Dietary carbohydrates raise blood glucose levels, and limiting carbohydrate intake improves
glycemia in patients with type 2 diabetes. Low carbohydrate intake (< 25 g) allows the body …

Comprehensive molecular and cellular phenotyping of human islets can enable deep
mechanistic insights for diabetes research. We established the Human Islet Data Analysis …

Objective Human embryonic stem cell (hESC; SC)-derived pancreatic β cells can be used to
study diabetes pathologies and develop cell replacement therapies. Although current …

In 2021, the diabetes mellitus field celebrated the centenary of the discovery of insulin.
Furthermore, in 2022, the US Food and Drug Administration approved two new treatments …

Insulin dependency arises from autoimmunity that targets the β cells of the pancreas,
resulting in Type 1 diabetes (T1D). Despite the fact that T1D patients require insulin for …

Glucose-stimulated insulin release from pancreatic β-cells is critical for maintaining blood
glucose homeostasis. An abrupt increase in blood glucose concentration evokes a rapid …