Molecular therapies and precision medicine for hepatocellular carcinoma

JM Llovet, R Montal, D Sia, RS Finn - Nature reviews Clinical oncology, 2018 - nature.com
The global burden of hepatocellular carcinoma (HCC) is increasing and might soon surpass
an annual incidence of 1 million cases. Genomic studies have established the landscape of …

Evidence-based management of hepatocellular carcinoma: systematic review and meta-analysis of randomized controlled trials (2002–2020)

PK Haber, M Puigvehí, F Castet, V Lourdusamy… - Gastroenterology, 2021 - Elsevier
Background & Aims Hepatocellular carcinoma (HCC) is a leading cause of cancer-related
mortality, with a rapidly changing landscape of treatments. In the past 20 years, numerous …

Apatinib as second-line or later therapy in patients with advanced hepatocellular carcinoma (AHELP): a multicentre, double-blind, randomised, placebo-controlled …

S Qin, Q Li, S Gu, X Chen, L Lin, Z Wang… - The lancet …, 2021 - thelancet.com
Background Inhibition of vascular endothelial growth factor receptor (VEGFR) has shown
antitumour activity in advanced hepatocellular carcinoma, but few studies of VEGFR …

[PDF][PDF] Trial design and endpoints in hepatocellular carcinoma: AASLD consensus conference

JM Llovet, A Villanueva, JA Marrero, M Schwartz… - …, 2021 - Wiley Online Library
Hepatocellular carcinoma (HCC) is the fourth leading cause of cancer-related mortality
worldwide.(1, 2) This neoplasm has some unique characteristics. It occurs in most cases …

EASL clinical practice guidelines: management of hepatocellular carcinoma

PR Galle, A Forner, JM Llovet, V Mazzaferro… - Journal of …, 2018 - Elsevier
Liver cancer is the fifth most common cancer and the second most frequent cause of cancer-
related death globally. Hepatocellular carcinoma represents about 90% of primary liver …

SIRveNIB: selective internal radiation therapy versus sorafenib in Asia-Pacific patients with hepatocellular carcinoma

PKH Chow, M Gandhi, SB Tan, MW Khin… - Journal of clinical …, 2018 - ascopubs.org
Purpose Selective internal radiation therapy or radioembolization (RE) shows efficacy in
unresectable hepatocellular carcinoma (HCC) limited to the liver. This study compared the …

EASL–EORTC clinical practice guidelines: management of hepatocellular carcinoma

European Association For The Study Of … - Journal of …, 2012 - journal-of-hepatology.eu
EASL–EORTC Clinical Practice Guidelines (CPG) on the management of hepatocellular
carcinoma (HCC) define the use of surveillance, diagnosis, and therapeutic strategies …

Randomized, multicenter, open-label study of oxaliplatin plus fluorouracil/leucovorin versus doxorubicin as palliative chemotherapy in patients with advanced …

S Qin, Y Bai, HY Lim, S Thongprasert… - Journal of Clinical …, 2013 - ascopubs.org
Purpose To determine whether FOLFOX4 (infusional fluorouracil, leucovorin, and
oxaliplatin) administered as palliative chemotherapy to patients with advanced …

[HTML][HTML] EASL–EORTC clinical practice guidelines: management of hepatocellular carcinoma

EO for Research… - Journal of …, 2012 - Elsevier
EASL–EORTC Clinical Practice Guidelines (CPG) on the management of hepatocellular
carcinoma (HCC) define the use of surveillance, diagnosis, and therapeutic strategies …

[HTML][HTML] Hepatocellular carcinoma (HCC): beyond sorafenib—chemotherapy

DW Kim, C Talati, R Kim - Journal of gastrointestinal oncology, 2017 - ncbi.nlm.nih.gov
Hepatocellular carcinoma (HCC) is the most common primary liver cancer with poor
prognosis. The incidence of HCC and HCC-related deaths have increased over the last …