Tissue inhibitor of metalloproteinase 3 (TIMP3) is unique among the four TIMPs due to its
extracellular matrix (ECM)-binding property and broad range of inhibitory substrates that …

Metalloproteinases were first identified as collagen cleaving enzymes and are now
appreciated to play important roles in a wide variety of biological processes. The aberrant …

Osteoarthritis (OA) is the most common degenerative joint disease. In 1999, two members of
the A Disintegrin and Metalloproteinase with Thrombospondin Motifs (ADAMTS) family of …

Highlights•Inhibition of metalloproteinases has great significance for developing new
therapeutics.•Engineering protein-based inhibitors of metalloproteinases provide higher …

Osteoarthritis is a common, degenerative joint disease with significant socio-economic
impact worldwide. There are currently no disease-modifying drugs available to treat the …

The low-density lipoprotein receptor-related protein 1 (LRP1) is a cell-surface receptor
ubiquitously expressed in various tissues. It plays tissue-specific roles by mediating …

Abstract Background and Objective Osteoarthritis (OA) is a pervasive and debilitating
disease, wherein degeneration of cartilage features prominently. Despite extensive …

Bone marrow mesenchymal stem cells (BMSCs)-based engineered cartilage usually faces
the significant challenge of endochondral ossification tendency in an ectopic environment …

Osteoarthritis (OA) is the most prevalent chronic degenerative joint disease. It weakens the
motor function of patients and imposes a significant economic burden on society. The …

Metalloproteinases remain important players in arthritic disease, in part because members
of this large enzymatic family, namely matrix metalloproteinase-1 (MMP-1) and MMP-13, are …