Mitochondria are one of the most important organelles in cells. Mitochondria are semi-
autonomous organelles with their own genetic system, and can independently replicate …

Novel classes of small and long non-coding RNAs (ncRNAs) are being characterized at a
rapid pace, driven by recent paradigm shifts in our understanding of genomic architecture …

Abstract tRNAscan-SE has been widely used for transfer RNA (tRNA) gene prediction for
over twenty years, developed just as the first genomes were decoded. With the massive …

Mitochondria generate most cellular energy via oxidative phosphorylation. Twenty-two
species of mitochondrial (mt-) tRNAs encoded in mtDNA translate essential subunits of the …

Mutations of the mitochondrial genome (mtDNA) underlie a substantial portion of
mitochondrial disease burden. These disorders are currently incurable and effectively …

High-throughput RNA sequencing has accelerated discovery of the complex regulatory roles
of small RNAs, but RNAs containing modified nucleosides may escape detection when …

Monogenic Mitochondrial Disorders | New England Journal of Medicine Skip to main content The
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Mitochondria are eukaryotic organelles that generate most of the energy in the cell by
oxidative phosphorylation (OXPHOS). Each mitochondrion contains multiple copies of a …

Aminoacyl‐tRNA synthetases (ARSs) are essential and ubiquitous 'house‐keeping'enzymes
responsible for charging amino acids to their cognate tRNAs and providing the substrates for …

Understanding regulation of mitochondrial DNA (mtDNA) expression is of considerable
interest given that mitochondrial dysfunction is important in human pathology and aging …