Oxidative stress in the pathophysiology of type 2 diabetes and related complications: Current therapeutics strategies and future perspectives

JS Bhatti, A Sehrawat, J Mishra, IS Sidhu… - Free Radical Biology …, 2022 - Elsevier
Abstract Type 2 diabetes (T2DM) is a persistent metabolic disorder rising rapidly worldwide.
It is characterized by pancreatic insulin resistance and β-cell dysfunction. Hyperglycemia …

Vitamin C supplementation for diabetes management: A comprehensive narrative review

SA Mason, L Parker, P van der Pligt… - Free Radical Biology and …, 2023 - Elsevier
Growing evidence suggests that vitamin C supplementation may be an effective adjunct
therapy in the management of people with diabetes. This paper critically reviews the current …

The effect of diet and lifestyle on the course of diabetic retinopathy—a review of the literature

A Bryl, M Mrugacz, M Falkowski, K Zorena - Nutrients, 2022 - mdpi.com
Diabetes is a major social problem. As shown by epidemiological studies, the world
incidence of diabetes is increasing and so is the number of people suffering from its …

Nutritional and medical food therapies for diabetic retinopathy

C Shi, P Wang, S Airen, C Brown, Z Liu, JH Townsend… - Eye and Vision, 2020 - Springer
Diabetic retinopathy (DR) is a form of microangiopathy. Reducing oxidative stress in the
mitochondria and cell membranes decreases ischemic injury and end-organ damage to the …

Vitreous antioxidants, degeneration, and vitreo-retinopathy: exploring the links

E Ankamah, J Sebag, E Ng, JM Nolan - Antioxidants, 2019 - mdpi.com
The transparent vitreous body, which occupies about 80% of the eye's volume, is laden with
numerous enzymatic and non-enzymatic antioxidants that could protect the eye from …

What else can we do to prevent diabetic retinopathy?

R Simó, C Hernández - Diabetologia, 2023 - Springer
The classical modifiable factors associated with the onset and progression of diabetic
retinopathy are the suboptimal control of blood glucose levels and hypertension, as well as …

Intraocular fluid biomarkers (liquid biopsy) in human diabetic retinopathy

E Midena, L Frizziero, G Midena, E Pilotto - Graefe's Archive for Clinical …, 2021 - Springer
Purpose This article aims to review the impact of detecting and quantifying intraocular
biomarkers (liquid biopsy) in both aqueous and vitreous humor in eyes of people affected by …

Adjuvant therapies in diabetic retinopathy as an early approach to delay its progression: the importance of oxidative stress and inflammation

RR Robles-Rivera… - Oxidative medicine …, 2020 - Wiley Online Library
Diabetes mellitus (DM) is a progressive disease induced by a sustained state of chronic
hyperglycemia that can lead to several complications targeting highly metabolic cells …

Update on the effects of antioxidants on diabetic retinopathy: In vitro experiments, animal studies and clinical trials

JJ Garcia-Medina, E Rubio-Velazquez… - Antioxidants, 2020 - mdpi.com
Current therapies for diabetic retinopathy (DR) incorporate blood glucose and blood
pressure control, vitrectomy, photocoagulation, and intravitreal injections of anti-vascular …

Importance of the use of oxidative stress biomarkers and inflammatory profile in aqueous and vitreous humor in diabetic retinopathy

AK López-Contreras, MG Martínez-Ruiz… - Antioxidants, 2020 - mdpi.com
Diabetic retinopathy is one of the leading causes of visual impairment and morbidity
worldwide, being the number one cause of blindness in people between 27 and 75 years …