Blood-brain barrier (BBB) remains a significant obstacle to drug therapy for brain diseases.
Focused ultrasound (FUS) combined with microbubbles (MBs) can locally and transiently …

In the last couple of decades, ultrasound-driven microbubbles have proven excellent
candidates for local drug delivery applications. Besides being useful drug carriers …

The physiology of the vasculature in the central nervous system (CNS), which includes the
blood–brain barrier (BBB) and other factors, complicates the delivery of most drugs to the …

Susceptibility-weighted imaging (SWI) is a new neuroimaging technique, which uses tissue
magnetic susceptibility differences to generate a unique contrast, different from that of spin …

Purpose To determine if focused ultrasound disruption of the blood-brain barrier (BBB) can
be safely controlled by using real-time modulation of treatment pressures on the basis of …

Focused Ultrasound (FUS) in combination with gaseous microbubbles has emerged as a
potential new means of effective drug delivery to the brain. Recent research has shown that …

Malignant glioma is one of the most challenging central nervous system (CNS) diseases,
which is typically associated with high rates of recurrence and mortality. Current surgical …

Purpose To demonstrate the feasibility of using focused ultrasound to enhance delivery of 1,
3-bis (2-chloroethyl)-1-nitrosourea (BCNU) to glioblastomas in rats with induced tumors and …

Focused ultrasound with microbubbles promises unprecedented advantages for blood-brain
barrier disruption over existing intracranial drug delivery methods, as well as a significant …

The blood-brain barrier, while fundamental in maintaining homeostasis in the central
nervous system, is a bottleneck to achieving efficacy for numerous therapeutics. Improved …