Spermatogenesis is the process by which a single spermatogonium develops into 256
spermatozoa, one of which will fertilize the ovum. Since the 1950s when the stages of the …

The attachment of cells to the extracellular matrix is of crucial importance in the maintenance
of tissue structure and integrity. In stratified epithelia such as in skin as well as in other …

In a recently developed human breast cancer model, treatment of tumor cells in a 3-
dimensional culture with inhibitory β1-integrin antibody or its Fab fragments led to a striking …

Human skin consists of a stratified, cellular epidermis and an underlying dermis of
connective tissue [1–5]. The dermal–epidermal junction is undulating in section; ridges of …

Spermatogenesis is an intriguing but complicated biological process. However, many
studies since the 1960s have focused either on the hormonal events of the hypothalamus …

Integrin α6β4 is a cellular adhesion molecule that binds to laminins in the extracellular
matrix and nucleates the formation of hemidesmosomes. During carcinoma progression …

Ecotourism is increasingly being advanced as a strategy to help address economic and
social problems in local communities, and as an appropriate and effective tool of …

We demonstrate that the α6β4 integrin promotes carcinoma invasion through a preferential
and localized targeting of phosphoinositide-3 OH kinase (PI3K) activity. Stable expression of …

Interactions of cells with the extracellular matrix are essential for the control of tissue
remodelling, cell migration, and embryogenesis. At the cell–extracellular matrix contact …

Abstract α6β4 integrin and the Met receptor for HGF have been shown independently to
promote invasive growth. We demonstrate here that Met selectively associates with α6β4. In …