Influenza epidemics and pandemics still represent a severe public health threat and cause
significant morbidity and mortality worldwide. As intracellular parasites, influenza viruses are …

PB1-F2 is an accessory protein of most human, avian, swine, equine, and canine influenza
A viruses (IAVs). Although it is dispensable for virus replication and growth, it plays …

The ubiquitin system denotes a potent post-translational modification machinery that is
capable of activation or deactivation of target proteins through reversible linkage of a single …

Flu, a viral infection caused by the influenza virus, is still a global public health concern with
potential to cause seasonal epidemics and pandemics. Vaccination is considered the most …

Throughout various stages of its life cycle, influenza A virus relies heavily on host cellular
machinery, including the post-translational modifications (PTMs) system. During infection …

Human infection with avian influenza A (H5N1) and (H7N9) viruses causes severe
respiratory diseases. PB1-F2 protein is a critical virulence factor that suppresses early type I …

The influenza A endoribonuclease PA-X regulates virulence and transmission of the virus by
reducing host gene expression and thus regulating immune responses to influenza A virus …

Influenza A virus (IAV) causes not only seasonal respiratory illness, but also outbreaks of
more severe disease and pandemics when novel strains emerge as a result of reassortment …

A severe course of acute respiratory disease caused by influenza A virus (IAV) infection is
often linked with subsequent bacterial superinfection, which is difficult to cure. Thus …

Influenza virus exploits cellular factors to complete each step of viral replication. Yet, multiple
host proteins actively block replication. Consequently, infection success depends on the …