The effects of insulin and type 1 insulin‐like growth factor (IGF–1) on metabolism, growth
and survival are mediated by their association with specific receptor tyrosine kinases, which …

Growth-factor receptor bound protein 10 (Grb10) is a signal adapter protein encoded by an
imprinted gene that has roles in growth control, cellular proliferation, and insulin signaling …

Variants in the growth factor receptor-bound protein 10 (GRB10) gene were in a GWAS meta-
analysis associated with reduced glucose-stimulated insulin secretion and increased risk of …

Metformin improves insulin sensitivity in insulin sensitive tissues such as liver, muscle and
fat. However, the functional roles and the underlying mechanism of metformin action in …

Identification of key regulators of lipid metabolism and thermogenic functions has important
therapeutic implications for the current obesity and diabetes epidemic. Here, we show that …

Pancreatic β cell failure is a hallmark of diabetes. However, the causes of β cell failure
remain incomplete. Here, we report the identification of tetranectin (TN), an adipose tissue …

Unresolved ER stress followed by cell death is recognized as the main cause of a multitude
of pathologies including neonatal diabetes. A systematic analysis of the mechanisms of β …

Complex diseases result from molecular changes induced by multiple genetic factors and
the environment. To derive a systems view of how genetic loci interact in the context of tissue …

Aims/hypothesis Better understanding of how genetic and epigenetic components control
beta cell differentiation and function is key to the discovery of novel therapeutic approaches …

The domestic pig is an ideal “dual purpose” animal model for agricultural and biomedical
research. With the availability of genome editing tools such as clustered regularly …