Stem cell derived insulin producing cells or islets have shown promise in reversing Type 1
Diabetes (T1D), yet successful transplantation currently necessitates long‐term modulation …

Ameliorating graft injury induced by ischemia and hypoxia, expanding the donor pool, and
improving graft quality and recipient prognosis are still goals pursued by the transplant …

The tremendous diversity of life in the ocean has proven to be a rich source of inspiration for
drug discovery, with success rates for marine natural products up to 4 times higher than …

The medical device M101 is an extracellular hemoglobin featuring high oxygen-carrying
capabilities. Preclinical studies demonstrated its safety as an additive to organ preservation …

Oxygenated ex situ machine perfusion of donor livers is an alternative for static cold
preservation that can be performed at temperatures from 0° C to 37° C. Organ metabolism …

Chronic wounds have always been considered as “gordian knots” in medicine, in which
hypoxia plays a key role in blocking healing. To address this challenge, although tissue …

Hemoglobin is essential for maintaining cellular bioenergetic homeostasis through its ability
to bind and transport oxygen to the tissues. Besides its ability to transport oxygen …

The development of oxygen (O 2)-carrying blood substitutes has evolved from the goal of
replicating blood O 2 transport properties to that of preserving microvascular and organ …

The control of inflammation and infection is crucial for periodontal wound healing and
regeneration. M101, an oxygen carrier derived from Arenicola marina, was tested for its anti …

Static preservation is currently the most widely used organ preservation strategy; however,
decreased donor organ quality is impacting outcome negatively. M101 is an O 2 carrier with …