Cellular metabolism in hematopoietic stem cells (HSCs) is an area of intense research
interest, but the metabolic requirements of HSCs and their adaptations to their niches during …

Hematopoietic stem cells (HSCs), which govern the production of all blood lineages,
transition through a series of functional states characterized by expansion during fetal …

Stem cell niches are composed of dynamic microenvironments that support stem cells over a
lifetime. The emerging niche is distinct from the adult because its main role is to support the …

Clinical transplants of hematopoietic stem cells (HSC) can provide a lifesaving therapy for
many hematological diseases; however, therapeutic applications are hampered by donor …

Hematopoietic stem cells (HSCs) support haematopoiesis throughout life and give rise to the
whole variety of cells of the immune system. Developing in the early embryo, passing …

Expansion of hematopoietic stem cells (HSCs) for therapeutic purposes has been a “holy
grail” in the field for many years. Ex vivo expansion of HSCs can help to overcome material …

The main hematopoietic stem cell (HSC) functions, self-renewal and differentiation, are
finely regulated by both intrinsic mechanisms such as transcriptional and epigenetic …

Not all hematopoietic stem cells (HSCs) are alike. They differ in their physical characteristics
such as cell cycle status and cell surface marker phenotype, they respond to different …

Despite improvements in clinical management, pregnancies complicated by pre-existing
diabetes mellitus, gestational diabetes mellitus or obesity carry substantial risks for parent …

The ZEB2 transcription factor has been demonstrated to play important roles in
hematopoiesis and leukemic transformation. ZEB1 is a close family member of ZEB2 but has …