The application of synthetic biology approaches to study development opens the possibility to build and manipulate developmental processes to understand them better. Researchers …
L Smirnova, T Hartung - Advanced Healthcare Materials, 2024 - Wiley Online Library
Brain organoids are 3D in vitro culture systems derived from human pluripotent stem cells that self‐organize to model features of the (developing) human brain. This review examines …
EG Kocaoglan, D Radhakrishnan… - Journal of …, 2023 - academic.oup.com
Plant morphology and anatomy strongly influence agricultural yield. Crop domestication has strived for desirable growth and developmental traits, such as larger and more fruits and …
Plant synthetic biology allows for the reprogramming of biological systems to promote sustainable agriculture. It has a range of applications, including improving nutritional quality …
NR Stillman, R Mayor - Seminars in Cell & Developmental Biology, 2023 - Elsevier
Understanding the mechanism by which cells coordinate their differentiation and migration is critical to our understanding of many fundamental processes such as wound healing …
During development, cells undergo symmetry breaking into differentiated subpopulations that self-organize into complex structures. 1, 2, 3, 4, 5 However, few tools exist to …
K Huang, Q Li, Y Xue, Q Wang, Z Chen, Z Gu - Advanced Drug Delivery …, 2023 - Elsevier
As alternative disease models, other than 2D cell lines and patient-derived xenografts, organoids have preferable in vivo physiological relevance. However, both endogenous and …
A major goal in synthetic development is to build gene regulatory circuits that control patterning. In natural development, an interplay between mechanical and chemical …
R Mousavi, D Lobo - npj Systems Biology and Applications, 2024 - nature.com
Gene regulatory mechanisms (GRMs) control the formation of spatial and temporal expression patterns that can serve as regulatory signals for the development of complex …