Selective serotonin reuptake inhibitors (SSRIs) are drugs of first choice in the therapy of
moderate to severe depression and anxiety disorders. Their primary mechanism of action is …

Since the crucial evolutionary change from an aqueous to a terrestrial environment, all living
organisms address the primordial task of equilibrating the ingestion/production of water and …

Context Thirst is a pervasive, intense, and distressing symptom in intensive care unit (ICU)
patients. Although thirst may be avoided and/or treated, scant data are available to help …

Aims Sertraline (SE) is one of the most prescribed medications for treating gestational
depression, anxiety and stress. However, little is known about its effects on nervous-system …

Background: Plasma aldosterone to renin ratio (ARR) is the most popular screening test for
primary aldosteronism (PAL). Certain medications are known to cause false-negative or …

Depression affects up to 15% of community-dwelling older adults (age> 65 years) in the
United States. Among elderly persons with significant medical illnesses, the prevalence of …

Serotonin is a neurotransmitter that is synthesized and released from the brainstem raphe
nuclei to affect many brain functions. It is well known that the activity of raphe serotonergic …

In times of stress the hypothalamic–pituitary–adrenal (HPA) axis is activated and releases
two neurohormones, corticotropin-releasing hormone (Crh) and arginine vasopressin (Avp) …

Vasopressin or arginine‐vasopressin (AVP) is a neuropeptide molecule known for its
antidiuretic effects and serves to regulate plasma osmolality and blood pressure. The …

Amidated peptides are critically involved in many physiological functions. Genetic deletion of
peptidylglycine α-amidating monooxygenase (PAM), the only enzyme that can synthesize …