Coeliac disease is a common enteropathy that occurs in genetically susceptible individuals
in response to the ingestion of gluten proteins present in wheat, rye and barley. Currently …

Growing evidence supports the hypothesis that changes in both the composition and
function of the intestinal microbiome are associated with a number of chronic inflammatory …

Background Variability in the health effects of dietary fiber might arise from inter-individual
differences in the gut microbiota's ability to ferment these substrates into beneficial …

Intestinal proteases mediate digestion and immune signalling, while increased gut
proteolytic activity disrupts the intestinal barrier and generates visceral hypersensitivity …

Proteases are an evolutionarily conserved family of enzymes that degrade peptide bonds
and have been implicated in several common gastrointestinal (GI) diseases. Although …

Bifidobacterium is a widely distributed commensal bacterial genus that displays beneficial
pro-homeostatic and anti-inflammatory immunomodulatory properties. Depletion or absence …

The significance of Bifidobacterium to human health can be appreciated from its early
colonization of the neonatal gut, where Bifidobacterium longum represents the most …

Since bifidobacteria are among the pioneering colonizers of the human infant gut, their
interaction with their host is believed to start soon following birth. Several members of the …

Celiac disease (CeD) is an immune-mediated enteropathy, and unique in that the specific
trigger is known: gluten. The current mainstay of therapy is a gluten-free diet (GFD). As novel …

Finely tuned mechanisms enable the gastrointestinal tract to break down dietary
components into nutrients without mounting, in the majority of cases, a dysregulated immune …