Macrophage polarization and its role in liver disease

C Wang, C Ma, L Gong, Y Guo, K Fu, Y Zhang… - Frontiers in …, 2021 - frontiersin.org
Macrophages are important immune cells in innate immunity, and have remarkable
heterogeneity and polarization. Under pathological conditions, in addition to the resident …

Macrophage reaction against biomaterials in the mouse model–Phenotypes, functions and markers

R Klopfleisch - Acta biomaterialia, 2016 - Elsevier
The foreign body reaction (FBR) is a response of the host tissue against more or less
degradation-resistant foreign macromolecular material. The reaction is divided into five …

Necroptosis contributes to chronic inflammation and fibrosis in aging liver

S Mohammed, N Thadathil, R Selvarani, EH Nicklas… - Aging cell, 2021 - Wiley Online Library
Inflammaging, characterized by an increase in low‐grade chronic inflammation with age, is a
hallmark of aging and is strongly associated with various age‐related diseases, including …

Integrin‐mediated interactions control macrophage polarization in 3D hydrogels

BH Cha, SR Shin, J Leijten, YC Li… - Advanced …, 2017 - Wiley Online Library
Adverse immune reactions prevent clinical translation of numerous implantable devices and
materials. Although inflammation is an essential part of tissue regeneration, chronic …

[HTML][HTML] Kupffer cell metabolism and function

AT Nguyen-Lefebvre, A Horuzsko - Journal of enzymology and …, 2015 - ncbi.nlm.nih.gov
Kupffer cells are resident liver macrophages and play a critical role in maintaining liver
functions. Under physiological conditions, they are the first innate immune cells and protect …

Macrophage modification strategies for efficient cell therapy

AS Poltavets, PA Vishnyakova, AV Elchaninov… - Cells, 2020 - mdpi.com
Macrophages, important cells of innate immunity, are known for their phagocytic activity,
capability for antigen presentation, and flexible phenotypes. Macrophages are found in all …

The flavonoid quercetin ameliorates liver inflammation and fibrosis by regulating hepatic macrophages activation and polarization in mice

X Li, Q Jin, Q Yao, B Xu, L Li, S Zhang… - Frontiers in …, 2018 - frontiersin.org
At present, there are no effective antifibrotic drugs for patients with chronic liver disease;
hence, the development of antifibrotic therapies is urgently needed. Here, we performed an …

Differential location and distribution of hepatic immune cells

MA Freitas-Lopes, K Mafra, BA David… - Cells, 2017 - mdpi.com
The liver is one of the main organs in the body, performing several metabolic and
immunological functions that are indispensable to the organism. The liver is strategically …

Macrophage phenotype in liver injury and repair

YY Sun, XF Li, XM Meng, C Huang… - … journal of immunology, 2017 - Wiley Online Library
Macrophages hold a critical position in the pathogenesis of liver injury and repair, in which
their infiltrations is regarded as a main feature for both acute and chronic liver diseases. It is …

Cardamom powder supplementation prevents obesity, improves glucose intolerance, inflammation and oxidative stress in liver of high carbohydrate high fat diet …

MM Rahman, MN Alam, A Ulla, FA Sumi… - Lipids in health and …, 2017 - Springer
Background Cardamom is a well-known spice in Indian subcontinent, used in culinary and
traditional medicine practices since ancient times. The current investigation was untaken to …