Asthma is an inflammatory disease of the airways that may result from exposure to allergens
or other environmental irritants, resulting in bronchoconstriction, wheezing, and shortness of …

In recent years, there has been an explosion of interest in how fibroblasts initiate, sustain,
and resolve inflammation across disease states. Fibroblasts contain heterogeneous subsets …

Asthma affects an estimated 262 million people worldwide and caused over 461,000 deaths
in 2019. The disease is characterized by chronic airway inflammation, reversible …

Recent developments in therapeutic strategies have provided alternatives to corticosteroids
as the cornerstone treatment for managing airway inflammation in asthma. The past two …

Background Fevipiprant, an oral antagonist of the prostaglandin D 2 receptor 2, reduced
sputum eosinophils and improved lung function in phase 2 trials of patients with asthma. We …

Allergies are typically endemic, complex and heterogeneous diseases with a high impact at
quality of life. Mechanistically, type 2 immune responses involving eosinophil and basophil …

Despite the availability of effective inhaled therapies, many patients with asthma have poor
asthma control. Uncontrolled asthma presents a significant burden on the patient and …

Senescent cells can drive age-related tissue dysfunction partially via a senescence-
associated secretory phenotype (SASP) involving proinflammatory and profibrotic factors …

Asthma increases worldwide without any definite reason and patient numbers double every
10 years. Drugs used for asthma therapy relax the muscles and reduce inflammation, but …

At present, there is no cure for asthma, and treatment typically involves therapies that
prevent or reduce asthma symptoms, without modifying the underlying disease. A “disease …