The reactive oxygen species (ROS)-producing enzyme NADPH oxidase (NOX) was first
identified in the membrane of phagocytic cells. For many years, its only known role was in …

Nicotinamide adenine dinucleotide phosphate (NADPH) oxidases (NOX) are enzymes that
generate superoxide or hydrogen peroxide from molecular oxygen utilizing NADPH as an …

Cisplatin is widely used for the treatment of a number of solid malignant tumors. However,
ototoxicity induced by cisplatin is an obstacle to effective treatment of tumors. The basis for …

Background Excessive accumulation of reactive oxygen species (ROS) has been
documented as the crucial cellular mechanism of cisplatin-induced ototoxicity. However …

Reactive oxygen species (ROS) are ubiquitous metabolic products and important cellular
signaling molecules that contribute to several biological functions. Pathophysiology arises …

Cisplatin is a commonly used antineoplastic agent that produces ototoxicity that is mediated
in part by increasing levels of reactive oxygen species (ROS) via the NOX3 NADPH oxidase …

Dysfunctional reactive oxygen species (ROS) signaling is considered an important disease
mechanism. Therapeutically, non-selective scavenging of ROS by antioxidants, however …

The lungs as the gateways of our body to the external environment are essential for gas
exchange. They are also exposed to toxicants from two sides, the airways and the …

In the United States, roughly 10% of the population is exposed daily to hazardous levels of
noise in the workplace. Twin studies estimate heritability for noise-induced hearing loss …

Rationale Neuropsychiatric disorders encompass a broad category of medical conditions
that include both neurology as well as psychiatry such as major depressive disorder, autism …