Matrix metalloproteinases (MMPs) are endopeptidases participating in physiological
processes of the brain, maintaining the blood–brain barrier integrity and playing a critical …

While AF most often occurs in the setting of atrial disease, current assessment and treatment
of patients with AF does not focus on the extent of the atrial myopathy that serves as the …

The best pharmacological treatment for each atrial fibrillation (AF) patient is unclear. We aim
to exploit AF simulations in 800 virtual atria to identify key patient characteristics that guide …

Particle matter (PM) is a complex mixture of particles suspended in the air, mainly caused by
fuel combustion from vehicles and industry, and has been related to pulmonary and …

Background Cardiac conduction properties exhibit large variability, and affect patient-
specific arrhythmia mechanisms. However, it is challenging to clinically measure conduction …

Objectives: The aim of this study was to demonstrate that a stochastic vector-based mapping
approach could guide ablation of atrial fibrillation (AF) drivers as evidenced by ablation …

Aims Conflicting data exist supporting differing mechanisms for sustaining ventricular
fibrillation (VF), ranging from disorganized multiple-wavelet activation to organized rotational …

Atrial fibrosis is an important component of the arrhythmic substrate in AF. Evidence
suggests that atrial fibrosis also plays a role in increasing the risk of stroke in patients with …

Ex vivo multicellular preparations are essential tools to study tissue physiology. Among
them, the recent methodological and technological developments in living myocardial slices …

Atrial fibrillation (AF) is characterized by disorganized rapid atrial electrical activity, which
leads to impaired atrial function, adverse hemodynamic effects, and increased …