Excitotoxicity, the specific type of neurotoxicity mediated by glutamate, may be the missing
link between ischemia and neuronal death, and intervening the mechanistic steps that lead …

A growing number of studies now suggest that the cellular mechanisms which normally
participate in signaling in the central nervous system (CNS) can be transformed by disease …

The human brain depends on its blood supply for a continuous supply of oxygen and
glucose. Irreversible brain damage occurs if blood flow is reduced below about 10 ml/100 g …

Phencyclidine (PCP), a dissociative anesthetic and widely abused psychotomimetic drug,
and MK-801, a potent PCP receptor ligand, have neuroprotective properties stemming from …

An influx of extraceUular Ca e+, with subsequent cellular Ca e+ overload, can clearly cause
certain types of cell death, and has been hypothesized to be a primary etiological event m …

Abstract l-Glutamate is the most abundant of a group of endogenous amino acids in the
mammalian central nervous system which presumably function as excitatory …

Recent studies suggest that excitatory amino acids (EAAs) have a wide variety of
physiological and pathophysiological roles during central nervous system (CNS) …

A major challenge in organic synthesis today is to devise reactions that can form several
carbon-carbon bonds in one operation leading to the construction of polycyclic structures …

Knowledge of the nature, prognosis, and ways to treat brain lesions in neonatal infants has
increased remarkably. Neonatal hypoxic-ischaemic encephalopathy (HIE) in term infants …

Perinatal cerebral hypoxia–ischemia remains a frequent cause of the chronic handicapping
conditions of cerebral palsy, mental retardation, learning disability, and epilepsy. 1 …