Use of brain biomechanical models for monitoring impact exposure in contact sports

S Ji, M Ghajari, H Mao, RH Kraft… - Annals of Biomedical …, 2022 - Springer
Head acceleration measurement sensors are now widely deployed in the field to monitor
head kinematic exposure in contact sports. The wealth of impact kinematics data provides …

The finite element analysis research on microneedle design strategy and transdermal drug delivery system

Q Yan, S Shen, Y Wang, J Weng, A Wan, G Yang… - Pharmaceutics, 2022 - mdpi.com
Microneedles (MNs) as a novel transdermal drug delivery system have shown great
potential for therapeutic and disease diagnosis applications by continually providing …

An anatomically detailed and personalizable head injury model: Significance of brain and white matter tract morphological variability on strain

X Li, Z Zhou, S Kleiven - Biomechanics and modeling in mechanobiology, 2021 - Springer
Finite element head (FE) models are important numerical tools to study head injuries and
develop protection systems. The generation of anatomically accurate and subject-specific …

Evaluation of tissue-level brain injury metrics using species-specific simulations

T Wu, M Hajiaghamemar, JS Giudice… - Journal of …, 2021 - liebertpub.com
Traumatic brain injury (TBI) is a significant public health burden, and the development of
advanced countermeasures to mitigate and prevent these injuries during automotive, sports …

Integrating human and nonhuman primate data to estimate human tolerances for traumatic brain injury

T Wu, F Sato, J Antona-Makoshi… - Journal of …, 2022 - asmedigitalcollection.asme.org
Traumatic brain injury (TBI) contributes to a significant portion of the injuries resulting from
motor vehicle crashes, falls, and sports collisions. The development of advanced …

[HTML][HTML] A quantitative relationship between rotational head kinematics and brain tissue strain from a 2-D parametric finite element analysis

RW Carlsen, AL Fawzi, Y Wan, H Kesari, C Franck - Brain Multiphysics, 2021 - Elsevier
Given the complex nature of traumatic brain injury (TBI), assessment of injury risk directly
from kinematic measures of head motion remains a challenge. Despite this challenge …

An image registration-based morphing technique for generating subject-specific brain finite element models

JS Giudice, A Alshareef, T Wu, CA Gancayco… - Annals of Biomedical …, 2020 - Springer
Finite element (FE) models of the brain are crucial for investigating the mechanisms of
traumatic brain injury (TBI). However, FE brain models are often limited to a single …

The White Matter Fiber Tract Deforms Most in the Perpendicular Direction During In Vivo Volunteer Impacts

Z Zhou, C Olsson, TC Gasser, X Li… - Journal of …, 2024 - liebertpub.com
White matter (WM) tract-related strains are increasingly used to quantify brain mechanical
responses, but their dynamics in live human brains during in vivo impact conditions remain …

Toward a comprehensive delineation of white matter tract-related deformation

Z Zhou, X Li, Y Liu, M Fahlstedt, M Georgiadis… - Journal of …, 2021 - liebertpub.com
Finite element (FE) models of the human head are valuable instruments to explore the
mechanobiological pathway from external loading, localized brain response, and resultant …

Calibration of a heterogeneous brain model using a subject-specific inverse finite element approach

JS Giudice, A Alshareef, T Wu, AK Knutsen… - … in Bioengineering and …, 2021 - frontiersin.org
Central to the investigation of the biomechanics of traumatic brain injury (TBI) and the
assessment of injury risk from head impact are finite element (FE) models of the human …