Molecular mechanisms of the cardiotoxicity of the proteasomal-targeted drugs bortezomib and carfilzomib

BB Hasinoff, D Patel, X Wu - Cardiovascular toxicology, 2017 - Springer
Bortezomib and carfilzomib are anticancer drugs that target the proteasome. However, these
agents have been shown to exhibit some specific cardiac toxicities by as yet unknown …

E3 ubiquitin ligases as novel targets for inflammatory diseases

SK Goru, A Pandey, AB Gaikwad - Pharmacological Research, 2016 - Elsevier
Ubiquitination is one of the post translational modifications which decide the fate of various
proteins in the cells, by either directing them towards proteasomal degradation or …

Reversible heart failure after bortezomib treatment in a patient with multiple myeloma

J Song, H Kim, S Shin, I Kim, D Oh, S Chong - The Korean Journal of …, 2015 - ekjm.org
Bortezomib (Velcade®) came into the spotlight as a target therapy for multiple myeloma. It
acts through reversible inhibition of intracellular proteasomes, which triggers apoptosis, with …

[图书][B] Proteasomal Regulation of rDNA Transcription and Skeletal Muscle Hypertrophy

P Chandler - 2018 - search.proquest.com
Muscle growth is advantageous not only because of its roles in mobility and breathing, but
because increases in muscle mass increase physical strength, reduces the risk of injury …

Bortezomib-Induced Cardiac Dysfunction in a Patient with Plasma Cell Leukemia–A Remote Complication

Z Rafiq, M Taj, T Shamsi - National Journal of Health Sciences, 2016 - ojs.njhsciences.com
Bortezomib is an important proteasome inhibitor widely used in plasma cell neoplasms. An
acute cardiac dysfunction is not a frequent side effect of bortezomib, but it is mentioned in …

[PDF][PDF] 다발골수종환자에서보르테조밉(bortezomib) 투여후발생한심부전1 예

송지현, 김희경, 신석표, 김인재, 오도연… - 대한내과 …, 2015 - pdfs.semanticscholar.org
Bortezomib (Velcade®) came into the spotlight as a target therapy for multiple myeloma. It
acts through reversible inhibition of intracellular proteasomes, which triggers apoptosis, with …