The emergence of coronavirus disease 2019 (COVID‐19), caused by the severe acute
respiratory syndrome coronavirus 2 (SARS‐CoV‐2) has become a major global public …

ABSTRACT A mechanistic explanation for the tolerance limits of animals at high
temperatures is still missing, but one potential target for thermal failure is the electrical …

Pancreatic cancer is an extremely malignant digestive tract tumor. With the increase of
chemotherapeutic resistance of pancreatic cancer, clinical treatment is in a dilemma. Hence …

Background: Elevated intracardiac pressure attributable to heart failure induces electrical
and structural remodeling in the left atrium (LA) that begets atrial myopathy and arrhythmias …

During the past few decades, cardiovascular research has increasingly focused on systemic
inflammatory mechanisms, particularly in the field of atherosclerosis but also in association …

Posttranslational regulation of cardiac NaV1. 5 channels is critical in modulating channel
expression and function, yet their regulation by phosphorylation of accessory proteins has …

Nav1. 5 is the predominant cardiac sodium channel subtype, encoded by the SCN5A gene,
which is involved in the initiation and conduction of action potentials throughout the heart …

Shortly after cardiac Na+ channels activate and initiate the action potential, inactivation
ensues within milliseconds, attenuating the peak Na+ current, INa, and allowing the cell …

Fibroblast growth factor homologous factors (FHFs) are intracellular proteins which regulate
voltage-gated sodium (Na v) channels in the brain and other tissues. FHF dysfunction has …

Objective Fibroblast growth factor homologous factors (FHFs) are brain and cardiac sodium
channel‐binding proteins that modulate channel density and inactivation gating. A recurrent …