Artificial biocatalytic linear cascades for preparation of organic molecules

JH Schrittwieser, S Velikogne, M Hall… - Chemical …, 2018 - ACS Publications
The review compiles artificial cascades involving enzymes with a focus on the last 10 years.
A cascade is defined as the combination of at least two reaction steps in a single reaction …

Comparative analysis of the chemical and biochemical synthesis of keto acids

Z Luo, S Yu, W Zeng, J Zhou - Biotechnology advances, 2021 - Elsevier
Keto acids are essential organic acids that are widely applied in pharmaceuticals,
cosmetics, food, beverages, and feed additives as well as chemical synthesis. Currently …

Development of a synthetic live bacterial therapeutic for the human metabolic disease phenylketonuria

VM Isabella, BN Ha, MJ Castillo, DJ Lubkowicz… - Nature …, 2018 - nature.com
Phenylketonuria (PKU) is a genetic disease that is characterized by an inability to
metabolize phenylalanine (Phe), which can result in neurotoxicity. To provide a potential …

Synthesis of D‐ and L‐Phenylalanine Derivatives by Phenylalanine Ammonia Lyases: A Multienzymatic Cascade Process

F Parmeggiani, SL Lovelock, NJ Weise… - Angewandte …, 2015 - Wiley Online Library
The synthesis of substituted d‐phenylalanines in high yield and excellent optical purity,
starting from inexpensive cinnamic acids, has been achieved with a novel one‐pot approach …

l-Amino acid oxidase as biocatalyst: a dream too far?

L Pollegioni, P Motta, G Molla - Applied microbiology and biotechnology, 2013 - Springer
Abstract l-Amino acid oxidase (LAAO) is a flavoenzyme containing non-covalently bound
flavin adenine dinucleotide, which catalyzes the stereospecific oxidative deamination of l …

[图书][B] Handbook of chiral chemicals

D Ager - 2005 - taylorfrancis.com
As pharmaceutical companies look to develop single enantiomers as drug candidates,
chemists are increasingly faced with the problems associated with this subclass of organic …

Breaking the mirror: L-amino acid deaminase, a novel stereoselective biocatalyst

G Molla, R Melis, L Pollegioni - Biotechnology advances, 2017 - Elsevier
Enantiomerically pure amino acids are of increasing interest for the fine chemical,
agrochemicals and pharmaceutical industries. During past years l-amino acids have been …

A new bacterial L-amino acid oxidase with a broad substrate specificity: purification and characterization

B Geueke, W Hummel - Enzyme and Microbial Technology, 2002 - Elsevier
The Gram-positive bacterium Rhodococcus opacus DSM 43250 produces an l-amino acid
oxidase (l-AAO) with a very broad substrate specificity. This enzyme has been purified to …

Amine–boranes: effective reducing agents for the deracemisation of dl-amino acids using l-amino acid oxidase from Proteus myxofaciens

FR Alexandre, DP Pantaleone, PP Taylor… - Tetrahedron …, 2002 - Elsevier
The deracemisation of dl-α-amino acids using l-amino acid oxidase from Proteus
myxofaciens and amine-boranes as chemical reducing agents has been investigated …

Biotechnological production of alpha-keto acids: current status and perspectives

Y Song, J Li, H Shin, L Liu, G Du, J Chen - Bioresource technology, 2016 - Elsevier
Abstract Alpha-keto (α-keto) acids are used widely in feeds, food additives, pharmaceuticals,
and in chemical synthesis processes. Although most α-keto acids are currently produced by …