Relative hypercoagulopathy of the SARS-CoV-2 beta and delta variants when compared to the less severe omicron variants is related to TEG parameters, the extent of …

LM Grobbelaar, A Kruger, C Venter… - … in thrombosis and …, 2022 - thieme-connect.com
Earlier variants of SARS-CoV-2 have been associated with hypercoagulability and an
extensive formation of fibrin amyloid microclots, which are considered to contribute to the …

Perioperative considerations in management of the severely bleeding coagulopathic patient

G Erdoes, D Faraoni, A Koster, ME Steiner… - Obstetric Anesthesia …, 2024 - journals.lww.com
This clinical review explored coagulopathy in severely bleeding patients after major surgery
(eg, cardiac surgery with cardiopulmonary bypass or CPB), serious trauma, and postpartum …

Point-of-care, goal-directed management of bleeding in trauma patients

J Zipperle, FCF Schmitt, H Schöchl - Current opinion in critical …, 2023 - journals.lww.com
POC SCTs are not able to characterise the complexity of trauma-associated coagulopathy.
VETs provide a rapid estimation of underlying haemostatic disorders, thereby providing …

SHock-INduced Endotheliopathy (SHINE): A mechanistic justification for viscoelastography-guided resuscitation of traumatic and non-traumatic shock

CM Bunch, E Chang, EE Moore, HB Moore… - Frontiers in …, 2023 - frontiersin.org
Irrespective of the reason for hypoperfusion, hypocoagulable and/or hyperfibrinolytic
hemostatic aberrancies afflict up to one-quarter of critically ill patients in shock. Intensivists …

[HTML][HTML] Early goal-directed hemostatic therapy for severe acute bleeding management in the intensive care unit: a narrative review

T Crochemore, K Görlinger, MD Lance - Anesthesia & Analgesia, 2024 - journals.lww.com
This is a narrative review of the published evidence for bleeding management in critically ill
patients in different clinical settings in the intensive care unit (ICU). We aimed to describe …

[PDF][PDF] Optimizing Traumatic Brain Injury Management: A Multidisciplinary Approach and Lessons Learned from a Complex Case

I Karunarathna, K Kusumarathna… - Uva Clinical Lab …, 2024 - researchgate.net
strategies to optimize patient outcomes. We present a case of a 32-year-old male who
suffered severe TBI following a motorcycle accident, emphasizing the complexity and …

Viscoelastic testing: Critical appraisal of new methodologies and current literature

GD Wool, T Carll - International Journal of Laboratory …, 2023 - Wiley Online Library
Abstract United States Food and Drug Administration (FDA)‐approved viscoelastic testing
(VET) methodologies have significantly changed in the last 10 years, with the availability of …

International council for standardisation in haematology recommendations on fibrinogen assays, thrombin clotting time and related tests in the investigation of …

I Mackie, A Casini, M Pieters, R Pruthi… - … journal of laboratory …, 2024 - Wiley Online Library
This guidance was prepared on behalf of the International Council for Standardisation in
Haematology (ICSH) by an international working group of clinicians and scientists. The …

Massive trauma and resuscitation strategies

CM Galbraith, BM Wagener… - …, 2023 - anesthesiology.theclinics.com
With transfusion ongoing, the patient was rushed to the operating room (OR) for a
thoracotomy to determine the source of bleeding where arterial and central access was …

Basic Principles of Rotational Thromboelastometry (ROTEM®) and the Role of ROTEM—Guided Fibrinogen Replacement Therapy in the Management of …

M Drotarova, J Zolkova, KM Belakova, M Brunclikova… - Diagnostics, 2023 - mdpi.com
Rotational thromboelastometry (ROTEM) is a viscoelastic method, which provides a
graphical and numerical representation of induced hemostasis in whole blood samples. Its …