Pharmacological management of apathy in dementia

L Azhar, RW Kusumo, G Marotta, KL Lanctôt… - CNS drugs, 2022 - Springer
Apathy is a highly prevalent symptom of dementia. Despite its association with faster
cognitive and functional decline, decreased quality of life and increased mortality, no …

Revisiting apathy in Alzheimer's disease: From conceptualization to therapeutic approaches

AL Teixeira, MM Gonzales, LC De Souza… - Behavioural …, 2021 - Wiley Online Library
Apathy is a neurobehavioral syndrome characterized by impaired motivation for goal‐
directed behaviors and cognitive activity, alongside blunted affect. Apathy is a common …

[HTML][HTML] The effect of reminiscence therapy using virtual reality on apathy in residential aged care: Multisite nonrandomized controlled trial

D Saredakis, HAD Keage, M Corlis, ES Ghezzi… - Journal of medical …, 2021 - jmir.org
Background Apathy is a frequent and underrecognized neurological disorder symptom.
Reduced goal-directed behavior caused by apathy is associated with poor outcomes for …

Apathy in Alzheimer's disease: A neurocircuitry based perspective

SF Mehak, AB Shivakumar, V Saraf… - Ageing Research …, 2023 - Elsevier
In addition to memory deficits and other cognitive disturbances, patients with Alzheimer's
disease (AD) experience neuropsychiatric symptoms, notably apathy, which is a state of …

Stakeholders' perspectives on adapting the World Health Organization iSupport for Dementia in Australia

LD Xiao, S McKechnie, L Jeffers, A De Bellis… - …, 2021 - journals.sagepub.com
Background In Australia, informal caregivers (family, friends and neighbours) play a crucial
role in supporting people with dementia to remain at home. Within the community aged care …

Effect of the MAGL/FAAH dual inhibitor JZL-195 on streptozotocin-induced Alzheimer's disease-like sporadic dementia in mice with an emphasis on Aβ, HSP-70 …

S Bajaj, S Zameer, S Jain, V Yadav… - ACS chemical …, 2022 - ACS Publications
Alzheimer's disease is identified by pathological hallmarks such as intracellular
neurofibrillary tangles (NFTs) and extracellular amyloid β plaques. Several hypotheses exist …

Interventional study to evaluate the clinical effects and safety of the nutraceutical compound BrainUp-10® in a cohort of patients with Alzheimer's disease: A …

L Guzman-Martinez, GA Farías… - Journal of …, 2021 - content.iospress.com
Background: Clinically-evaluated nutraceuticals are candidates for Alzheimer's disease (AD)
prevention and treatment. Phase I studies showed biological safety of the nutraceutical …

Degenerative dementias: Alterations of emotions and mood disorders

MF Mendez - Handbook of Clinical Neurology, 2021 - Elsevier
Degenerative dementias such as Alzheimer's disease and frontotemporal dementia result in
distinct alterations in emotional processing, emotional experiences, and mood. The …

Prevalent, persistent, and impairing: longitudinal course and impact of apathy in Alzheimer's disease

HT Grossman, M Sano, A Aloysi… - Alzheimer's & …, 2021 - Wiley Online Library
Introduction Understanding of the natural history of apathy and its impact on patient function
is limited. This study examines, in a large, national sample of Alzheimer's disease (AD) …

Virtual reality intervention to improve apathy in residential aged care: protocol for a multisite non-randomised controlled trial

D Saredakis, HAD Keage, M Corlis, T Loetscher - BMJ open, 2021 - bmjopen.bmj.com
Introduction Apathy is a prevalent neuropsychiatric symptom for older adults residing in
aged care. Left untreated, apathy has been associated with accelerated cognitive decline …