Mitochondria are subcellular organelles involved in essential cellular functions, including
cytosolic calcium regulation, cell apoptosis, and reactive oxygen species production. They …

Mitochondria are the main organelles that produce adenosine 5′‐triphosphate (ATP) and
reactive oxygen species (ROS) in eukaryotic cells and meanwhile susceptible to oxidative …

Cancer chemoprevention is the most effective approach to control cancer in the population.
Despite significant progress, chemoprevention has not been widely adopted because …

Coenzyme Q10 (CoQ10 or ubiquinone) is a mobile proton and electron carrier of the
mitochondrial respiratory chain with antioxidant properties widely used as an antiaging …

Oxidative stress nearly always accompanies all stages of cancer development. At the early
stages, antioxidants may help to reduce reactive oxygen species (ROS) production and …

Mitochondria play multifaceted roles in malignant tumor progression. Beyond their
bioenergetic role, mitochondria are essential for providing malignant cells a higher plasticity …

Metabolic rewiring offers novel therapeutic opportunities in cancer. Until recently, there was
scant information regarding soft tissue sarcomas, due to their heterogeneous tissue origin …

Background Preconditioning of the heart ameliorates doxorubicin (Dox)-induced
cardiotoxicity. We tested whether pretreating cardiomyocytes by mitochondrial-targeted …

In cancer, mitochondrial functions are commonly altered. Directly involved in metabolic
reprogramming, mitochondrial plasticity confers to cancer cells a high degree of adaptability …

Despite the significant progress in the fields of biology, physiology, molecular medicine, and
pharmacology; the designation of the properties of nitrogen monoxide in the regulation of life …