Tissue-specific engineering: 3D bioprinting in regenerative medicine

Z Wang, W Kapadia, C Li, F Lin, RF Pereira… - Journal of Controlled …, 2021 - Elsevier
Despite its complexity, the human body is composed of only four basic tissue types, namely
epithelial, connective, muscular and nervous tissues. Notably, each tissue is an assemblage …

Corneal surgery in keratoconus: which type, which technique, which outcomes?

F Arnalich-Montiel, JL Alió del Barrio, JL Alió - Eye and vision, 2016 - Springer
Keratoconus is a disease characterized by progressive thinning, bulging, and distortion of
the cornea. Advanced cases usually present with loss of vision due to high irregular …

Corneal endothelium: developmental strategies for regeneration

J Zavala, GR Lopez Jaime, CA Rodriguez Barrientos… - Eye, 2013 - nature.com
The main treatment available for restoration of the corneal endothelium is keratoplasty. This
procedure is faced with several difficulties, including the shortage of donor tissue, post …

Corneal regeneration using adipose-derived mesenchymal stem cells

JL Alió del Barrio, A De la Mata, MP De Miguel… - Cells, 2022 - mdpi.com
Adipose-derived stem cells are a subtype of mesenchymal stem cell that offers the important
advantage of being easily obtained (in an autologous manner) from low invasive …

Decellularized human cornea for reconstructing the corneal epithelium and anterior stroma

MA Shafiq, RA Gemeinhart, BYJT Yue… - Tissue engineering part …, 2012 - liebertpub.com
In this project, we strived to develop a decellularized human cornea to use as a scaffold for
reconstructing the corneal epithelium and anterior stroma. Human cadaver corneas were …

Acellular human corneal matrix sheets seeded with human adipose-derived mesenchymal stem cells integrate functionally in an experimental animal model

JLA del Barrio, M Chiesa, N Garagorri… - Experimental eye …, 2015 - Elsevier
Purpose To evaluate the in vivo biocompatibility of grafts composed of sheets of
decellularized human corneal stroma with or without the recellularization of human adipose …

Corneal stromal regeneration: a review of human clinical studies in keratoconus treatment

M El Zarif, JL Alió, JL Alió del Barrio… - Frontiers in …, 2021 - frontiersin.org
The use of advanced therapies with stem cells to reconstruct the complex tissue of corneal
stroma has gained interest in recent years. Besides, collagen-based scaffolds …

3D bioprinting of corneal models: A review of the current state and future outlook

L Balters, S Reichl - Journal of Tissue Engineering, 2023 - journals.sagepub.com
The cornea is the outermost layer of the eye and serves to protect the eye and enable vision
by refracting light. The need for cornea organ donors remains high, and the demand for an …

The potential role of bioengineering and three-dimensional printing in curing global corneal blindness

PE Ludwig, TJ Huff, JM Zuniga - Journal of Tissue …, 2018 - journals.sagepub.com
An insufficiency of accessible allograft tissue for corneal transplantation leaves many
impaired by untreated corneal disease. There is promise in the field of regenerative …

Adipose derived stem cells for corneal wound healing after laser induced corneal lesions in mice

M Zeppieri, ML Salvetat, A Beltrami, D Cesselli… - Journal of Clinical …, 2017 - mdpi.com
The aim of our study was to assess the clinical effectiveness of topical adipose derived stem
cell (ADSC) treatment in laser induced corneal wounds in mice by comparing epithelial …