Recent Advances in the Regioselective Synthesis of Indoles via C–H Activation/Functionalization
Indole is an important heterocyclic motif that occurs ubiquitously in bioactive natural
products and pharmaceuticals. Immense efforts have been devoted to the synthesis of …
products and pharmaceuticals. Immense efforts have been devoted to the synthesis of …
How much successful are the medicinal chemists in modulation of SIRT1: A critical review
Silent information regulator two homologue one (SIRT1) is the most widely studied member
of the sirtuin family related to histone deacetylases class III super-family using nicotinamide …
of the sirtuin family related to histone deacetylases class III super-family using nicotinamide …
Ruthenium-Catalyzed Redox-Neutral C–H Activation via N–N Cleavage: Synthesis of N-Substituted Indoles
Z Zhang, H Jiang, Y Huang - Organic letters, 2014 - ACS Publications
The first Ru-catalyzed redox-neutral C–H activation reaction via N–N bond cleavage is
reported. Pyrazolidin-3-one is demonstrated as an internally oxidative directing group that …
reported. Pyrazolidin-3-one is demonstrated as an internally oxidative directing group that …
A recyclable magnetic nanoparticles supported antimony catalyst for the synthesis of N-substituted pyrroles in water
FP Ma, PH Li, BL Li, LP Mo, N Liu, HJ Kang… - Applied Catalysis A …, 2013 - Elsevier
A new magnetic nanoparticle-supported antimony catalyst was prepared and evaluated as a
recoverable catalyst for Clauson-Kaas reaction. The reaction proceeds efficiently in aqueous …
recoverable catalyst for Clauson-Kaas reaction. The reaction proceeds efficiently in aqueous …
One-pot organocatalyzed synthesis of tricyclic indolizines
LA Zeoly, LV Acconcia, MT Rodrigues… - Organic & …, 2023 - pubs.rsc.org
Indolizines and their saturated derivatives are important structural motifs present in several
biologically active compounds of both natural and synthetic origin. We describe herein a one …
biologically active compounds of both natural and synthetic origin. We describe herein a one …
Cyclopentannulated Dihydrotetraazapentacenes
R Heckershoff, S Maier, T Wurm… - … A European Journal, 2022 - Wiley Online Library
The transition‐metal‐catalyzed cyclization of bissilylethynylated N, N'‐
dihydrotetraazapentacene (TIPS‐TAP‐H2) into bissilylated cyclopenta [fg, qr] pentacenes is …
dihydrotetraazapentacene (TIPS‐TAP‐H2) into bissilylated cyclopenta [fg, qr] pentacenes is …
Hexafluoroisopropanol-Mediated Intramolecular Ring-Opening Cyclization of Indolyl-N-Tethered Epoxides: Tether-Length-Controlled Synthesis of 1,7- and 1,2-Fused …
Despite having the capability to construct benzo-fused heterocycles in complete atom
economy and high chemo-, regio-, enantio-, and diastereoselectivities, intramolecular …
economy and high chemo-, regio-, enantio-, and diastereoselectivities, intramolecular …
A new route to indoles via in situ desilylation–Sonogashira strategy: identification of novel small molecules as potential anti-tuberculosis agents
A new Pd/C-mediated tandem reaction has been developed for the one pot synthesis of
indoles containing an o-(RSO2NH) C6H4 group at the C-2 position. The methodology …
indoles containing an o-(RSO2NH) C6H4 group at the C-2 position. The methodology …
Activators of sirtuin-1 and their involvement in cardioprotection
C Granchi, F Minutolo - Current Medicinal Chemistry, 2018 - ingentaconnect.com
SIRT1 is a nicotinamide adenosine dinucleotide (NAD+)-dependent deacetylase, which
removes acetyl groups from many target proteins, such as histone proteins, transcription …
removes acetyl groups from many target proteins, such as histone proteins, transcription …
Aminocatalyzed cascade synthesis of enantioenriched 1, 7‐annulated indoles from indole‐7‐carbaldehyde derivatives and α, β‐unsaturated aldehydes
M Giardinetti, X Moreau, V Coeffard… - Advanced Synthesis & …, 2015 - Wiley Online Library
We report herein a new cascade strategy for the enantioselective synthesis of 1, 7‐
annulated indoles based on iminium‐enamine activation. A careful study of the indole …
annulated indoles based on iminium‐enamine activation. A careful study of the indole …