Mycobacterium tuberculosis and its clever approaches to escape the deadly macrophage

V Krishnan, S Nath, P Nair, B Das - World Journal of Microbiology and …, 2023 - Springer
Abstract Mycobacterium tuberculosis (Mt. b), a deadly disease causer, is a facultative
parasite. This microorganism has developed several methods to defend itself, once …

Promising Ursolic Acid as a Novel Antituberculosis Agent: Current Progress and Challenges

DAE Pitaloka, Y Syaputri, P Nurlilasari… - Drug Design …, 2024 - Taylor & Francis
Tuberculosis (TB) stands as the second most prevalent cause of global human mortality from
infectious diseases. In 2022, the World Health Organization documented an estimated …

Temperature-Induced Restructuring of Mycolic Acid Bilayers Modeling the Mycobacterium tuberculosis Outer Membrane: A Molecular Dynamics Study

AV Vasyankin, SV Panteleev, IS Steshin, EA Shirokova… - Molecules, 2024 - mdpi.com
The emergence of new drug-resistant strains of the tuberculosis pathogen Mycobacterium
tuberculosis (Mtb) is a new challenge for modern medicine. Its resistance capacity is closely …

Depletion of essential mycobacterial gene glmM reduces pathogen survival and induces host-protective immune responses against tuberculosis

M Agarwal, A Bhaskar, B Singha… - Communications …, 2024 - nature.com
The limitations of TB treatment are the long duration and immune-dampening effects of anti-
tuberculosis therapy. The Cell wall plays a crucial role in survival and virulence; hence …

Defensins: A novel weapon against Mycobacterium tuberculosis?

X Gao, J Feng, L Wei, P Dong, J Chen, L Zhang… - International …, 2024 - Elsevier
Tuberculosis (TB) is a serious airborne communicable disease caused by organisms of the
Mycobacterium tuberculosis (Mtb) complex. Although the standard treatment antimicrobials …

[HTML][HTML] Differential Host Gene Expression in Response to Infection by Different Mycobacterium tuberculosis Strains—A Pilot Study

D Megawati, LY Armitige, L Tazi - Microorganisms, 2024 - mdpi.com
Tuberculosis (TB) represents a global public health threat and is a leading cause of
morbidity and mortality worldwide. Effective control of TB is complicated with the emergence …

Searching for Chemical Agents Suppressing Substrate Microbiota in White-Rot Fungi Large-Scale Cultivation

A Maruška, R Mickienė, V Kaškonienė, S Grigiškis… - Microorganisms, 2024 - mdpi.com
Edible fungi are a valuable resource in the search for sustainable solutions to environmental
pollution. Their ability to degrade organic pollutants, extract heavy metals, and restore …

Chemistry and Biology of Coenzyme F420 in Tuberculosis treatment

SMS Chauhan - Chemical Biology Letters, 2024 - pubs.thesciencein.org
Coenzyme F420 is one of the ancient and rare coenzymes in biology. The unique
electrochemical properties of F420 are compared with the ubiquitous flavin coenzymes FMN …

ERK1/2-CEBPB Axis-Regulated hBD1 Enhances Anti-Tuberculosis Capacity in Alveolar Type II Epithelial Cells

Y Chen, Z Han, S Zhang, H Liu, K Wang, J Liu… - International Journal of …, 2024 - mdpi.com
Tuberculosis, caused by Mycobacterium tuberculosis (Mtb), remains a global health crisis
with substantial morbidity and mortality rates. Type II alveolar epithelial cells (AEC-II) play a …

[HTML][HTML] Enhanced Antimicrobial Peptide Response Following Bacillus Calmette–Guerin Vaccination in Elderly Individuals

AN Pandiarajan, NP Kumar, A Rajamanickam… - Vaccines, 2024 - mdpi.com
Background: Antimicrobial peptides are an important component of host defense against
Mycobacterium tuberculosis. However, the ability of BCG to induce AMPs as part of its …