In this review we give an update on the mechanisms of naturally acquired immunity against
Streptococcus pneumoniae, one of the major human bacterial pathogens that is a common …

ABSTRACT Introduction: Epidemiologic evaluations of Streptococcus pneumoniae
nasopharyngeal (NP) colonization and pneumococcal disease suggest that newer …

Summary Background Pneumococcal conjugate vaccines (PCVs) induce serotype-specific
IgG antibodies, effectively reducing vaccine-serotype carriage and invasive pneumococcal …

Streptococcus pneumoniae serotype 3 remains a significant cause of morbidity and mortality
worldwide, despite inclusion in the 13-valent pneumococcal conjugate vaccine (PCV13) …

Naturally acquired immunity against invasive pneumococcal disease (IPD) is thought to be
dependent on anti-capsular antibody. However nasopharyngeal colonisation by …

B cells play a central role in adaptive immune processes, mainly through the production of
antibodies. The maturation of the B cell system with age is poorly studied. We extensively …

Streptococcus pneumoniae (pneumococcus) is a nasopharyngeal commensal and
respiratory pathogen. This study characterises the immunoglobulin G (IgG) repertoire …

Streptococcus pneumoniae (pneumococcus) is a leading cause of severe infections among
children and adults. Interactions between commensal microbes in the upper respiratory tract …

Streptococcus pneumoniae (the pneumococcus) is a nasopharyngeal commensal and
respiratory pathogen. Most isolates express a capsule, the species-wide diversity of which …

Successful infection by mucosal pathogens requires overcoming the mucus barrier. To
better understand this key step, we performed a survey of the interactions between human …