Proteins may vary from being rigid to having flexible regions to being completely disordered,
either as an intrinsically disordered protein (IDP) or having specific intrinsically disordered …

Alzheimer's disease (AD) is the most common, age-dependent neurodegenerative disorder.
While AD has been intensively studied from different aspects, there is no effective cure for …

Cytoplasmic deposition of aberrantly misfolded α-synuclein (α-Syn) is a common feature of
synucleinopathies, including Parkinson's disease (PD). However, the precise pathogenic …

Alzheimer's disease (AD) is a primary form of dementia with debilitating consequences, but
no effective cure is available. While the pathophysiology of AD remains multifactorial, the …

Proteins, under certain circumstances such as defective quality control mechanism,
mutations and altered environmental conditions, undergo misfolding and assemble into …

Given the significance of protein aggregation in proteinopathies and the development of
therapeutic protein pharmaceuticals, revamped interest in assessing and modelling the …

Misfolding and self-assembly of several intrinsically disordered proteins into ordered β-sheet-
rich amyloid aggregates emerged as hallmarks of several neurodegenerative disorders …

There have been significant advances in the formulation and stabilization of proteins in the
liquid state over the past years since our previous review. Our mechanistic understanding of …

Insulin, an essential peptide hormone, conjointly regulates blood glucose levels by its
receptor and it is used as vital drug to treat diabetes. This therapeutic hormone may undergo …

Aggregation of a protein is associated with several biological and industrial processes:
some wanted and some unwanted. An understanding of the mechanism of modulation of …