Neuroprotective roles of Apelin-13 in neurological diseases
Y Zhang, W Jiang, W Sun, W Guo, B Xia, X Shen… - Neurochemical …, 2023 - Springer
Apelin is a natural ligand for the G protein-coupled receptor APJ, and the apelin/APJ system
is widely distributed in vivo. Among the apelin family, apelin-13 is the major apelin isoform in …
is widely distributed in vivo. Among the apelin family, apelin-13 is the major apelin isoform in …
Physical exercise-induced myokines in neurodegenerative diseases
B Lee, M Shin, Y Park, SY Won, KS Cho - International journal of …, 2021 - mdpi.com
Neurodegenerative diseases (NDs), such as Alzheimer's disease (AD), Parkinson's disease
(PD), Huntington's disease (HD), and amyotrophic lateral sclerosis (ALS), are disorders …
(PD), Huntington's disease (HD), and amyotrophic lateral sclerosis (ALS), are disorders …
Apelin-13 suppresses neuroinflammation against cognitive deficit in a streptozotocin-induced rat model of Alzheimer's disease through activation of BDNF-TrkB …
H Luo, Y Xiang, X Qu, H Liu, C Liu, G Li… - Frontiers in …, 2019 - frontiersin.org
Alzheimer's disease (AD), a progressive neurodegenerative disease characterized by
impairments of cognitive function as a result of synaptic deficits and neuronal loss, is …
impairments of cognitive function as a result of synaptic deficits and neuronal loss, is …
Apelin/APJ system: an emerging therapeutic target for neurological diseases
A Li, Q Zhao, L Chen, Z Li - Molecular Biology Reports, 2023 - Springer
Apelin, an endogenous ligand for the G protein-coupled receptor APJ, is extensively
expressed in various systems, especially the nervous system. This article reviews the role of …
expressed in various systems, especially the nervous system. This article reviews the role of …
Apelin-36 mediates neuroprotective effects by regulating oxidative stress, autophagy and apoptosis in MPTP-induced Parkinson's disease model mice
J Zhu, W Gao, X Shan, C Wang, H Wang, Z Shao… - Brain research, 2020 - Elsevier
Abstract Parkinson's disease (PD), a common human neurodegenerative disorder, is
characterized by the presence of intraneuronal Lewy bodies composed principally of …
characterized by the presence of intraneuronal Lewy bodies composed principally of …
Apelin-13 protects dopaminergic neurons against rotenone—induced neurotoxicity through the AMPK/mTOR/ULK-1 mediated autophagy activation
P Chen, Y Wang, L Chen, N Song, J Xie - International Journal of …, 2020 - mdpi.com
Parkinson's disease (PD) is characterized by the progressive loss of dopaminergic neurons
in the substantia nigra pars compacta. Several brain–gut peptides are able to exert …
in the substantia nigra pars compacta. Several brain–gut peptides are able to exert …
Neuroprotective gain of Apelin/APJ system
JX Zhou, NN Shuai, B Wang, X Jin, X Kuang, SW Tian - Neuropeptides, 2021 - Elsevier
Apelin is an endogenous ligand of G protein-coupled receptor APJ. In recent years, many
studies have shown that the apelin/APJ system has neuroprotective properties, such as anti …
studies have shown that the apelin/APJ system has neuroprotective properties, such as anti …
Apelin, a promising target for Alzheimer disease prevention and treatment
J Masoumi, M Abbasloui, R Parvan… - Neuropeptides, 2018 - Elsevier
Alzheimer's disease (AD) is a progressive neurodegenerative disease with high outbreak
rates. It is estimated that about 35 million individuals around the world suffered from …
rates. It is estimated that about 35 million individuals around the world suffered from …
Apelin-13 protects dopaminergic neurons in MPTP-induced Parkinson's disease model mice through inhibiting endoplasmic reticulum stress and promoting …
J Zhu, S Dou, Y Jiang, J Chen, C Wang, B Cheng - Brain Research, 2019 - Elsevier
The dopaminergic neurodegeneration in the substantia nigra pars compacta (SNpc) and
striatum of the midbrain is the important pathological feature of Parkinson's disease (PD). It …
striatum of the midbrain is the important pathological feature of Parkinson's disease (PD). It …
The apelin/APJ system in psychosis and neuropathy
SY Lv, WD Chen, YD Wang - Frontiers in pharmacology, 2020 - frontiersin.org
Apelin, an endogenous neuropeptide, has been identified as the cognate ligand for the G-
protein-coupled receptor APJ. Apelin, APJ messenger RNA, and protein are widely …
protein-coupled receptor APJ. Apelin, APJ messenger RNA, and protein are widely …