OSA is a chronic treatable sleep disorder and a frequent comorbidity in patients with type 2
diabetes. Cardinal features of OSA, including intermittent hypoxemia and sleep …

A large body of epidemiologic evidence has linked insufficient sleep duration and quality to
the risk of obesity, insulin resistance and type 2 diabetes. To address putative causal …

Westernized populations are plagued by a plethora of chronic non-infectious degenerative
diseases, termed as “civilization diseases”, like obesity, diabetes, cardiovascular diseases …

Several articles have dealt with the importance and mechanisms of the sympathetic nervous
system alterations in experimental animal models of hypertension. This review addresses …

The cAMP-dependent protein kinase (PKA) system represents a primary cell-signaling
pathway throughout systems and across species. PKA facilitates the actions of hormones …

Abnormalities of glucose, insulin, and lipoprotein metabolism are common in patients with
hypertension. These changes can also be discerned in normotensive first-degree relatives …

Background Sleep disorders are increasingly associated with insulin resistance, glucose
intolerance, and type 2 diabetes mellitus. Whether the metabolic toll imposed by sleep …

Synchronization of molecular, metabolic, and cardiovascular circadian oscillations is
fundamental to human health. Sleep-disordered breathing, which disrupts such temporal …

The brain occupies a special hierarchical position in the organism. It is separated from the
general circulation by the blood-brain barrier, has high energy consumption and a low …

Although animal models of hypertension have clearly shown that high blood pressure is
associated with and is probably caused by an increase in sympathetic cardiovascular …