Promises and pitfalls of evaluating photoreceptor-based retinal disease with adaptive optics scanning light ophthalmoscopy (AOSLO)
Adaptive optics scanning light ophthalmoscopy (AOSLO) allows visualization of the living
human retina with exquisite single-cell resolution. This technology has improved our …
human retina with exquisite single-cell resolution. This technology has improved our …
[HTML][HTML] Adaptive optics imaging in inherited retinal diseases: A scoping review of the clinical literature
AC Britten-Jones, L Thai, JPM Flanagan… - Survey of …, 2024 - Elsevier
Adaptive optics (AO) imaging enables direct, objective assessments of retinal cells.
Applications of AO show great promise in advancing our understanding of the etiology of …
Applications of AO show great promise in advancing our understanding of the etiology of …
[HTML][HTML] Genotypic and phenotypic spectrum of foveal hypoplasia: a multicenter study
Purpose To characterize the genotypic and phenotypic spectrum of foveal hypoplasia (FH).
Design Multicenter, observational study. Participants A total of 907 patients with a confirmed …
Design Multicenter, observational study. Participants A total of 907 patients with a confirmed …
Challenges associated with ellipsoid zone intensity measurements using optical coherence tomography
KE Lee, H Heitkotter, J Carroll - Translational vision science & …, 2021 - tvst.arvojournals.org
Optical coherence tomography (OCT) allows noninvasive visualization of individual retinal
layers and has become a mainstay in the diagnosis and management of a wide range of …
layers and has become a mainstay in the diagnosis and management of a wide range of …
SLC38A8 mutations result in arrested retinal development with loss of cone photoreceptor specialization
Foveal hypoplasia, optic nerve decussation defects and anterior segment dysgenesis is an
autosomal recessive disorder arising from SLC38A8 mutations. SLC38A8 is a putative …
autosomal recessive disorder arising from SLC38A8 mutations. SLC38A8 is a putative …
Normal and abnormal foveal development
Normal foveal development begins in utero at midgestation with centrifugal displacement of
inner retinal layers (IRLs) from the location of the incipient fovea. The outer retinal changes …
inner retinal layers (IRLs) from the location of the incipient fovea. The outer retinal changes …
[HTML][HTML] Oculocutaneous albinism and ocular albinism overview
Oculocutaneous Albinism and Ocular Albinism Overview - Abstract - Europe PMC Sign in |
Create an account https://orcid.org Europe PMC Menu About Tools Developers Help …
Create an account https://orcid.org Europe PMC Menu About Tools Developers Help …
Prostaglandin-based rAAV-mediated glaucoma gene therapy in Brown Norway rats
KJ Chern, ER Nettesheim, CA Reid, NW Li… - Communications …, 2022 - nature.com
Prostaglandin analogs are first-line treatments for open angle glaucoma and while effective
at lowering intraocular pressure, they are undermined by patient non-compliance, causing …
at lowering intraocular pressure, they are undermined by patient non-compliance, causing …
[HTML][HTML] Characterization of retinal structure in ATF6-associated achromatopsia
RR Mastey, M Georgiou, CS Langlo… - … & visual science, 2019 - tvst.arvojournals.org
Purpose: Mutations in six genes have been associated with achromatopsia (ACHM):
CNGA3, CNGB3, PDE6H, PDE6C, GNAT2, and ATF6. ATF6 is the most recent gene to be …
CNGA3, CNGB3, PDE6H, PDE6C, GNAT2, and ATF6. ATF6 is the most recent gene to be …
Photoreceptor-based biomarkers in AOSLO retinal imaging
Improved understanding of the mechanisms underlying inherited retinal degenerations has
created the possibility of developing much needed treatments for these relentless, blinding …
created the possibility of developing much needed treatments for these relentless, blinding …