Glycoconjugates: synthesis, functional studies, and therapeutic developments
Glycoconjugates are major constituents of mammalian cells that are formed via covalent
conjugation of carbohydrates to other biomolecules like proteins and lipids and often …
conjugation of carbohydrates to other biomolecules like proteins and lipids and often …
Post-translational modifications of G Protein–Coupled receptors control cellular signaling dynamics in space and time
G protein–coupled receptors (GPCRs) are a large family comprising> 800 signaling
receptors that regulate numerous cellular and physiologic responses. GPCRs have been …
receptors that regulate numerous cellular and physiologic responses. GPCRs have been …
Virological characteristics of the SARS-CoV-2 XBB variant derived from recombination of two Omicron subvariants
Abstract In late 2022, SARS-CoV-2 Omicron subvariants have become highly diversified,
and XBB is spreading rapidly around the world. Our phylogenetic analyses suggested that …
and XBB is spreading rapidly around the world. Our phylogenetic analyses suggested that …
Virological characteristics of the SARS-CoV-2 Omicron BA. 2 subvariants, including BA. 4 and BA. 5
I Kimura, D Yamasoba, T Tamura, N Nao, T Suzuki… - Cell, 2022 - cell.com
After the global spread of the SARS-CoV-2 Omicron BA. 2, some BA. 2 subvariants,
including BA. 2.9. 1, BA. 2.11, BA. 2.12. 1, BA. 4, and BA. 5, emerged in multiple countries …
including BA. 2.9. 1, BA. 2.11, BA. 2.12. 1, BA. 4, and BA. 5, emerged in multiple countries …
Convergent evolution of SARS-CoV-2 Omicron subvariants leading to the emergence of BQ. 1.1 variant
In late 2022, various Omicron subvariants emerged and cocirculated worldwide. These
variants convergently acquired amino acid substitutions at critical residues in the spike …
variants convergently acquired amino acid substitutions at critical residues in the spike …
Virological characteristics of the SARS-CoV-2 Omicron XBB. 1.5 variant
T Tamura, T Irie, S Deguchi, H Yajima, M Tsuda… - Nature …, 2024 - nature.com
Abstract Circulation of SARS-CoV-2 Omicron XBB has resulted in the emergence of XBB.
1.5, a new Variant of Interest. Our phylogenetic analysis suggests that XBB. 1.5 evolved from …
1.5, a new Variant of Interest. Our phylogenetic analysis suggests that XBB. 1.5 evolved from …
Structure and gating mechanism of the α7 nicotinic acetylcholine receptor
CM Noviello, A Gharpure, N Mukhtasimova, R Cabuco… - Cell, 2021 - cell.com
The α7 nicotinic acetylcholine receptor plays critical roles in the central nervous system and
in the cholinergic inflammatory pathway. This ligand-gated ion channel assembles as a …
in the cholinergic inflammatory pathway. This ligand-gated ion channel assembles as a …
Human coronaviruses OC43 and HKU1 bind to 9-O-acetylated sialic acids via a conserved receptor-binding site in spike protein domain A
RJG Hulswit, Y Lang, MJG Bakkers… - Proceedings of the …, 2019 - National Acad Sciences
Human betacoronaviruses OC43 and HKU1 are endemic respiratory pathogens and, while
related, originated from independent zoonotic introductions. OC43 is in fact a host-range …
related, originated from independent zoonotic introductions. OC43 is in fact a host-range …
Structure of a human synaptic GABAA receptor
Fast inhibitory neurotransmission in the brain is principally mediated by the neurotransmitter
GABA (γ-aminobutyric acid) and its synaptic target, the type A GABA receptor (GABAA …
GABA (γ-aminobutyric acid) and its synaptic target, the type A GABA receptor (GABAA …
Crystal structure of rhodopsin bound to arrestin by femtosecond X-ray laser
G-protein-coupled receptors (GPCRs) signal primarily through G proteins or arrestins.
Arrestin binding to GPCRs blocks G protein interaction and redirects signalling to numerous …
Arrestin binding to GPCRs blocks G protein interaction and redirects signalling to numerous …