Evolution of innate immunity: clues from invertebrates via fish to mammals
K Buchmann - Frontiers in immunology, 2014 - frontiersin.org
Host responses against invading pathogens are basic physiological reactions of all living
organisms. Since the appearance of the first eukaryotic cells, a series of defense …
organisms. Since the appearance of the first eukaryotic cells, a series of defense …
[HTML][HTML] An expanded arsenal of immune systems that protect bacteria from phages
Bacterial anti-phage systems are frequently clustered in microbial genomes, forming
defense islands. This property enabled the recent discovery of multiple defense systems …
defense islands. This property enabled the recent discovery of multiple defense systems …
IL-17 is a neuromodulator of Caenorhabditis elegans sensory responses
Abstract Interleukin-17 (IL-17) is a major pro-inflammatory cytokine: it mediates responses to
pathogens or tissue damage, and drives autoimmune diseases. Little is known about its role …
pathogens or tissue damage, and drives autoimmune diseases. Little is known about its role …
New insight into the functions of the interleukin-17 receptor adaptor protein Act1 in psoriatic arthritis
MS Doyle, ES Collins, OM FitzGerald… - Arthritis research & …, 2012 - Springer
Recent genome-wide association studies have implicated the tumor necrosis factor receptor-
associated factor 3-interacting protein 2 (TRAF3IP2) gene and its product, nuclear factor …
associated factor 3-interacting protein 2 (TRAF3IP2) gene and its product, nuclear factor …
The psoriasis-associated D10N variant of the adaptor Act1 with impaired regulation by the molecular chaperone hsp90
C Wang, L Wu, K Bulek, BN Martin, JA Zepp… - Nature …, 2013 - nature.com
Act1 is an essential adaptor in interleukin 17 (IL-17)-mediated signaling and is recruited to
the receptor for IL-17 after stimulation with IL-17. Here we found that Act1 was a'client'protein …
the receptor for IL-17 after stimulation with IL-17. Here we found that Act1 was a'client'protein …
IL17 factors are early regulators in the gut epithelium during inflammatory response to Vibrio in the sea urchin larva
IL17 cytokines are central mediators of mammalian immunity. In vertebrates, these factors
derive from diverse cellular sources. Sea urchins share a molecular heritage with chordates …
derive from diverse cellular sources. Sea urchins share a molecular heritage with chordates …
Fusion transcripts FYN-TRAF3IP2 and KHDRBS1-LCK hijack T cell receptor signaling in peripheral T-cell lymphoma, not otherwise specified
Peripheral T-cell lymphoma (PTCL) is a heterogeneous group of non-Hodgkin lymphomas
with poor prognosis. Up to 30% of PTCL lack distinctive features and are classified as PTCL …
with poor prognosis. Up to 30% of PTCL lack distinctive features and are classified as PTCL …
FYN–TRAF3IP2 induces NF-κB signaling-driven peripheral T-cell lymphoma
Angioimmunoblastic T-cell lymphoma (AITL) and peripheral T-cell lymphoma not otherwise
specified (PTCL, NOS) have poor prognosis and, in most cases, lack driver actionable …
specified (PTCL, NOS) have poor prognosis and, in most cases, lack driver actionable …
Molecular characterization and evolution analysis of five interleukin-17 receptor genes in large yellow croaker Larimichthys crocea
Y Ding, C Ai, Y Mu, J Ao, X Chen - Fish & Shellfish Immunology, 2016 - Elsevier
Abstract Interleukin-17s (IL-17s) play critical roles in inflammatory response and host
defense against extracellular pathogens. IL-17s induce the immune response signaling …
defense against extracellular pathogens. IL-17s induce the immune response signaling …
MALT-1 mediates IL-17 neural signaling to regulate C. elegans behavior, immunity and longevity
Besides pro-inflammatory roles, the ancient cytokine interleukin-17 (IL-17) modulates neural
circuit function. We investigate IL-17 signaling in neurons, and the extent it can alter …
circuit function. We investigate IL-17 signaling in neurons, and the extent it can alter …