[HTML][HTML] Streptozotocin as a tool for induction of rat models of diabetes: A practical guide

A Ghasemi, S Jeddi - EXCLI journal, 2023 - ncbi.nlm.nih.gov
Streptozotocin (STZ) is the most used diabetogenic chemical for creating rat models of type
1 and type 2 diabetes. Despite~ 60 years of using STZ in animal diabetes research, some …

A practical guide for induction of type-2 diabetes in rat: Incorporating a high-fat diet and streptozotocin

S Gheibi, K Kashfi, A Ghasemi - Biomedicine & pharmacotherapy, 2017 - Elsevier
Prevalence of diabetes, a serious public health problem is rapidly increasing worldwide.
Type-2 diabetes is the common form of diabetes characterized by insulin resistance and …

Dietary flaxseed oil rich in omega-3 suppresses severity of type 2 diabetes mellitus via anti-inflammation and modulating gut microbiota in rats

L Zhu, L Sha, K Li, Z Wang, T Wang, Y Li, P Liu… - Lipids in health and …, 2020 - Springer
Background Type 2 diabetes mellitus (T2DM) is closely associated with hyperglycemia,
abnormal lipid profiles, chronic low-grade inflammation and gut dysbiosis. Dietary …

Streptozotocin-induced type 1 diabetes in rodents as a model for studying mitochondrial mechanisms of diabetic β cell glucotoxicity

J Wu, LJ Yan - Diabetes, metabolic syndrome and obesity: targets …, 2015 - Taylor & Francis
Chronic hyperglycemia and the corresponding glucotoxicity are the main pathogenic
mechanisms of diabetes and its complications. Streptozotocin (STZ)-induced diabetic animal …

Streptozotocin‐induced diabetic models in mice and rats

BL Furman - Current protocols in pharmacology, 2015 - Wiley Online Library
Streptozotocin (STZ) is an antibiotic that produces pancreatic islet β‐cell destruction and is
widely used experimentally to produce a model of type 1 diabetes mellitus (T1DM). Detailed …

Streptozotocin‐induced diabetic models in mice and rats

BL Furman - Current protocols, 2021 - Wiley Online Library
Streptozotocin (STZ) is an antibiotic that causes pancreatic islet β‐cell destruction and is
widely used experimentally to produce a model of type 1 diabetes mellitus (T1DM). Detailed …

Antidiabetic Potency, Antioxidant Effects, and Mode of Actions of Citrus reticulata Fruit Peel Hydroethanolic Extract, Hesperidin, and Quercetin in Nicotinamide …

AM Ali, MA Gabbar, SM Abdel-Twab… - Oxidative medicine …, 2020 - Wiley Online Library
This study is aimed at assessing the antihyperglycemic, antihyperlipidemic, and antioxidant
effects of Citrus reticulata (C. reticulata) fruit peel hydroethanolic extract and two flavonoids …

Navel orange peel hydroethanolic extract, naringin and naringenin have anti-diabetic potentials in type 2 diabetic rats

OM Ahmed, MA Hassan, SM Abdel-Twab… - Biomedicine & …, 2017 - Elsevier
Abstract The therapy of Type 2 Diabetes Mellitus (T2DM) stays a challenging issue. During
the last decade, there has been an interest in the expansion of anti-diabetic drugs especially …

The hepatoprotective effects of fennel seeds extract and trans‐Anethole in streptozotocin‐induced liver injury in rats

Z Samadi‐Noshahr, MAR Hadjzadeh… - Food science & …, 2021 - Wiley Online Library
Hypoglycemic, anti‐inflammatory, and antioxidant activities of fennel have been recorded in
numerous investigations. The study aimed to evaluate the protective effects of fennel or its …

Therapeutic efficacy of natural product 'C-phycocyanin'in alleviating streptozotocin-induced diabetes via the inhibition of glycation reaction in rats

A Husain, S Alouffi, A Khanam, R Akasha… - International Journal of …, 2022 - mdpi.com
Diabetes is a long-term metabolic disorder characterized by persistently elevated blood
sugar levels. Chronic hyperglycemia enhances glucose–protein interactions, leading to the …