Radon-222 is a naturally occurring radioactive gas that is responsible for approximately half
of the human annual background radiation exposure globally. Chronic exposure to radon …

The concept of DNA “repair centers” and the meaning of radiation-induced foci (RIF) in
human cells have remained controversial. RIFs are characterized by the local recruitment of …

Repair of double strand breaks (DSBs) is essential for cell survival and genome integrity.
While much is known about the molecular mechanisms involved in DSB repair and …

Protontherapy is a rapidly expanding radiotherapy modality where accelerated proton
beams are used to precisely deliver the dose to the tumor target but is generally considered …

Abstract Hirayama, R., Ito, A., Tomita, M., Tsukada, T., Yatagai, F., Noguchi, M., Matsumoto,
Y., Kase, Y., Ando, K., Okayasu, R., and Furusawa, F. Contributions of Direct and Indirect …

Biological effects of high-LET (linear energy transfer) radiation have received increasing
attention, particularly in the context of more efficient radiotherapy and space exploration …

Ionising radiation is incredibly effective at causing biological effects. This is due to the
unique way energy is deposited along highly structured tracks of ionisation and excitation …

Despite increasing use of proton therapy (PBT), several systematic literature reviews show
limited gains in clinical outcomes, with publications mostly devoted to recent technical …

The aim of this work is to predict relative biological effectiveness (RBE) for protons and
clinically relevant heavier ions, by using a simplified semi-empirical process based on …

Purpose: To better estimate relative biological effectiveness (RBE) in therapeutic proton
beams by using a modeled approach, in order to improve their clinical safety and …