Lymphopenia in COVID‐19: Therapeutic opportunities
Severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) is uncontrollably spread
all over the world. The host immune responses strongly try to confront it with all the potential …
all over the world. The host immune responses strongly try to confront it with all the potential …
CD4 T-cell exhaustion: does it exist and what are its roles in cancer?
In chronic infections and in cancer, persistent antigen stimulation under suboptimal
conditions can lead to the induction of T-cell exhaustion. Exhausted T cells are …
conditions can lead to the induction of T-cell exhaustion. Exhausted T cells are …
Peripheral and lung resident memory T cell responses against SARS-CoV-2
J Grau-Expósito, N Sánchez-Gaona, N Massana… - Nature …, 2021 - nature.com
Resident memory T cells (TRM) positioned within the respiratory tract are probably required
to limit SARS-CoV-2 spread and COVID-19. Importantly, TRM are mostly non-recirculating …
to limit SARS-CoV-2 spread and COVID-19. Importantly, TRM are mostly non-recirculating …
T-cell exhaustion in chronic infections: reversing the state of exhaustion and reinvigorating optimal protective immune responses
T-cell exhaustion is a phenomenon of dysfunction or physical elimination of antigen-specific
T cells reported in human immunodeficiency virus (HIV), hepatitis B virus (HBV), and …
T cells reported in human immunodeficiency virus (HIV), hepatitis B virus (HBV), and …
Distinct plasma immune signatures in ME/CFS are present early in the course of illness
M Hornig, JG Montoya, NG Klimas, S Levine… - Science …, 2015 - science.org
Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is an unexplained
incapacitating illness that may affect up to 4 million people in the United States alone. There …
incapacitating illness that may affect up to 4 million people in the United States alone. There …
SARS-CoV-2-associated lymphopenia: possible mechanisms and the role of CD147
S Shouman, N El-Kholy, AE Hussien… - Cell Communication and …, 2024 - Springer
T lymphocytes play a primary role in the adaptive antiviral immunity. Both lymphocytosis and
lymphopenia were found to be associated with severe acute respiratory syndrome …
lymphopenia were found to be associated with severe acute respiratory syndrome …
Immune cells and inflammation in diabetic nephropathy
Z Zheng, F Zheng - Journal of diabetes research, 2016 - Wiley Online Library
Diabetic nephropathy (DN) is a serious complication of diabetes. At its core, DN is a
metabolic disorder which can also manifest itself in terms of local inflammation in the …
metabolic disorder which can also manifest itself in terms of local inflammation in the …
Rationally combining anti-VEGF therapy with checkpoint inhibitors in hepatocellular carcinoma
Hepatocellular carcinoma (HCC) is a fatal disease with rising incidence in the world. For
advanced HCC, sorafenib, a multikinase inhibitor, is the only systemic therapy with proven …
advanced HCC, sorafenib, a multikinase inhibitor, is the only systemic therapy with proven …
Immunotherapy in hepatocellular carcinoma: Primed to make a difference?
JJ Harding, I El Dika, GK Abou‐Alfa - Cancer, 2016 - Wiley Online Library
Advanced hepatocellular carcinoma (HCC) carries a dismal prognosis and the current
treatment is limited to sorafenib, an agent with modest benefit. Preclinical data have …
treatment is limited to sorafenib, an agent with modest benefit. Preclinical data have …
Regulatory T-cells-related signature for identifying a prognostic subtype of hepatocellular carcinoma with an exhausted tumor microenvironment
G Zhang - Frontiers in Immunology, 2022 - frontiersin.org
Regulatory T-Cells (Tregs) are important in the progression of hepatocellular cancer (HCC).
The goal of this work was to look into Tregs-related genes and develop a Tregs-related …
The goal of this work was to look into Tregs-related genes and develop a Tregs-related …