Aging is a major cause of many degenerative diseases. The most intuitive consequence of
aging is mainly manifested on the skin, resulting in cumulative changes in skin structure …

Many recent advances have emerged in the telomere and telomerase fields. This Timeline
article highlights the key advances that have expanded our views on the mechanistic …

This protocol describes the use of TurboID and split-TurboID in proximity labeling
applications for mapping protein–protein interactions and subcellular proteomes in live …

Cellular senescence is an irreversible growth arrest that occurs as a result of different
damaging stimuli, including DNA damage, telomere shortening and dysfunction or …

Ageing is the predominant risk factor for many common diseases. Human premature ageing
diseases are powerful model systems to identify and characterize cellular mechanisms that …

Aging is the result of a gradual functional decline at the cellular, and ultimately, organismal
level, resulting in an increased risk of developing a variety of chronic illnesses, such as …

There are inherent limitations with traditional methods to study protein behavior or to
determine the constituency of proteins in discrete subcellular compartments. In response to …

Products of the LMNA gene, primarily lamin A and C, are key components of the nuclear
lamina, a proteinaceous meshwork that underlies the inner nuclear membrane and is …

Proteins are workhorses in the cell; they form stable and more often dynamic, transient
protein–protein interactions, assemblies, and networks and have an intimate interplay with …

Proximity‐dependent biotin identification (BioID) is a recently developed method that allows
the identification of proteins in the close vicinity of a protein of interest in living cells. BioID …